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Bioengineered Protein Fibers with Anti-Freezing Mechanical Behaviors

机译:Bioengineered Protein Fibers with Anti-Freezing Mechanical Behaviors

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摘要

Most biological protein fibers exhibit extraordinary mechanical performance at room temperatures but inferior freezing resistance. Maintaining fiber’s high strength and toughness under subzero conditions remains a great challenge. Herein, a class of freezing tolerant protein fibers is reported with favorable ice-phobic capacity and cryogenic mechanical performance by genetic engineering. Inspired by nature, chimeric recombinant proteins consist of highly ordered structural protein domains and antifreeze protein (AFP) modules, showing excellent ice recrystallization inhibition activity. Such features endow the resulting protein fibers with remarkable mechanical properties and good mechanical stability in subzero environments. In stark contrast to conventional fibers, the engineered protein fibers maintain high cryogenic stiffness and toughness even at ?20 and ?40 ℃. The synergistic contribution of structural protein and AFP plays an important role for the extraordinary anti-freezing mechanical behaviors. Thus, this study pioneers an engineering approach for the next generation of biological fibers with tailored applications in extreme settings.

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  • 来源
    《Advanced functional materials》 |2022年第48期|2209006.1-2209006.8|共8页
  • 作者单位

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,University of Science and Technology of China Hefei 230026, China;

    State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China;

    School of Chemistry and Molecular Engineering Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development East China Normal University Shanghai 200062, ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022, China,University of Science and Technology of China Hefei 230026, China,Department of Chemistry Tsinghua UniversCollege of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences Beijing 100049, China;

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  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类
  • 关键词

    antifreeze proteins; fibers; ice recrystallization inhibitions; mechanical performance; protein engineering;

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