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首页> 外文期刊>Autism research : >Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case–control study in Tianjin, China
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Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case–control study in Tianjin, China

机译：Association of urinary polycyclic aromatic hydrocarbon metabolites with symptoms among autistic children: A case–control study in Tianjin, China

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Abstract Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous pollutants that are associated with altered neurodevelopment and various neurodevelopmental disorders. However, studies evaluating internal biomarkers of PAH exposure in reference to the severity of autism spectrum disorder (ASD) symptomology and autistic behaviors are scarce. Hence, we conducted a case–control study evaluating 12 urinary hydroxylated PAH metabolites (i.e., hydroxy‐PAHs) in 101 children with autism and 101 neurotypical children, matching according to sex and age in a 1:1 ratio. In children with ASD, the severity of symptomology and autistic behaviors were assessed using the child autism rating scale (CARS) and the autism behavior checklist (ABC). We found that urinary levels of nine of the hydroxy‐PAHs were statistically significantly higher in the ASD group, with the exception of 2‐hydroxynaphthalene (2‐OHNap) and 4‐hydroxyphenanthrene (4‐OHPhe). Moreover, urinary hydroxy‐PAH levels were associated with ASD risk, with odds ratios ranging from 1.86 to 17.19. Exposures to 1‐hydroxynaphthalene (1‐OHNap, β?=?3.32), hydroxyphenanthrenes (1/2/3?+?9‐OHPhes, β?=?3.41–5.12), 1‐hydroxypyrene (1‐OH‐Pyr; β?=?3.91), 2‐hydroxybenzofuran (2‐OHDBF; β?=?3.93), and ∑OH‐PAHs (β?=?4.67) were positively associated with CARS scores after adjusting for covariates (all p?

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