Microbiota-brain interactions : Moving toward mechanisms in model organisms

Nagpal Jatin; Cryan John F.

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Microbiota-brain interactions : Moving toward mechanisms in model organisms

机译：Microbiota-brain interactions : Moving toward mechanisms in model organisms

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Changes in the microbiota are associated with alterations in nervous system structure-function and behavior and have been implicated in the etiology of neuropsychiatric and neurodegenerative disorders. Most of these studies have centered on mammalian models due to their phylogenetic proximity to humans. Indeed, the germ-free mouse has been a particularly useful model organism for investigating microbiota-brain interactions. However, microbiota-brain axis research on simpler genetic model organisms with a vast and diverse scientific toolkit (zebrafish, Drosophila melanogaster, and Caenorhabditis elegans) is now also coming of age. In this review, we summarize the current state of microbiota-brain axis research in rodents and humans, and then we elaborate and discuss recent research on the neurobiological and behavioral effects of the microbiota in the model systems of fish, flies, and worms. We propose that a cross-species, holistic and mechanistic approach to unravel the microbiota-brain communication is an essential step toward rational microbiota-based therapeutics to combat brain disorders.

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《Neuron》 |2021年第24期|3930-3953|共24页
作者
Nagpal Jatin; Cryan John F.;
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作者单位

APC Microbiome Ireland,Univ Coll Cork;

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原文格式 PDF
正文语种英语
中图分类神经病学;
关键词
GUT MICROBIOTA; INTESTINAL MICROBIOTA; COMMENSAL BACTERIA; SOCIAL-BEHAVIOR; STRESS-RESPONSE; NERVOUS-SYSTEM; ANIMAL-MODELS; DROSOPHILA; HOST; ZEBRAFISH;

Microbiota-brain interactions : Moving toward mechanisms in model organisms

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