Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination

Yazdi Seyed Amir Miratashi; Heshmati Marjan; Nadoushan Mohammadreza Jalali

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Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination

机译：Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination

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Background: Papillary thyroid cancer is the most common type of thyroid malignancies. For a more accurate diagnosis, immunohistochemistry has been used widely in recent years. Epithelial membrane antigen has been detected in several benign and malignant lesions, and its use as a marker of malignancy has been sought in some studies. Objectives: The current study aimed to determine the presence and level of expression of epithelial membrane antigen in papillary thyroid carcinoma and multinodular goiter. Methods: Eighty-five samples of papillary thyroid carcinoma and 40 cases of multinodular goiter were stained histochemically for epithelial membrane antigen. The intensity of staining was classified in a semi-quantitative manner (1+ to 4+). Demographic data of the index cases, history of metastasis, and lymph node involvement, if any, were collected as well. Results: All PTCs and 87.5% of MNGs were positive for EMA. EMA was expressed more strongly in PTCs than in MNGs (P < 0.00). EMA reactivity was directly associated with lymph node involvement, capsular invasion, and size of the tumor (P = 0.008, P < 0.001, and P < 0.001, respectively). The intensity level of 2 or higher had high specificity for differentiating PTC from MNG. Conclusions: Strong expression of EMA may be a good marker of malignancy in differentiating PTC from MNG. This marker may also be regarded as an index of invasive behavior of PTC.

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《iranian red crescent medical journal》 |2020年第7期|共5页
作者
Yazdi Seyed Amir Miratashi; Heshmati Marjan; Nadoushan Mohammadreza Jalali;
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作者单位

Shahed Univ;

Univ Tehran Med Sci;

Shahed UnivShahed Univ;

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正文语种英语
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Epithelial Membrane Antigen; Papillary Thyroid Carcinoma; Multinodular Goiter; Immunohistochemistry; Lymph Node Involvement; Capsular Invasion; MALIGNANT MESOTHELIOMA; CYTOKERATIN; HYPERPLASIA;

Epithelial Membrane Antigen in Papillary Thyroid Carcinoma and Multinodular Goiter; a Marker of Discrimination

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