Towards a definitive symptom structure of obsessive?compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals

MattiCervin; Euripedes C.Miguel; Ay?egül SelcenGülerYgor A.Ferr?oAy?e BurcuErdo?duLuisaLazaroSeblaG?k?eDaniel A.GellerYaseminYulaf?aziye SenemBa?gül?zlem?zcanKorayKarabekiro?luLeonardo F.FontenelleYank?YazganEric A.StorchJames F.LeckmanMaria Concei??odo RosárioDavidMataix-Cols

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Towards a definitive symptom structure of obsessive?compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals

机译：Towards a definitive symptom structure of obsessive?compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals

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Abstract Background The symptoms of obsessive?compulsive disorder (OCD) are highly heterogeneous and it is unclear what is the optimal way to conceptualize this heterogeneity. This study aimed to establish a comprehensive symptom structure model of OCD across the lifespan using factor and network analytic techniques.Methods A large multinational cohort of well-characterized children, adolescents, and adults diagnosed with OCD (N = 1366) participated in the study. All completed the Dimensional Yale-Brown Obsessive?Compulsive Scale, which contains an expanded checklist of 87 distinct OCD symptoms. Exploratory and confirmatory factor analysis were used to outline empirically supported symptom dimensions, and interconnections among the resulting dimensions were established using network analysis. Associations between dimensions and sociodemographic and clinical variables were explored using structural equation modeling (SEM).Results Thirteen first-order symptom dimensions emerged that could be parsimoniously reduced to eight broad dimensions, which were valid across the lifespan: Disturbing Thoughts, Incompleteness, Contamination, Hoarding, Transformation, Body Focus, Superstition, and Loss/Separation. A general OCD factor could be included in the final factor model without a significant decline in model fit according to most fit indices. Network analysis showed that Incompleteness and Disturbing Thoughts were most central (i.e. had most unique interconnections with other dimensions). SEM showed that the eight broad dimensions were differentially related to sociodemographic and clinical variables.Conclusions Future research will need to establish if this expanded hierarchical and multidimensional model can help improve our understanding of the etiology, neurobiology and treatment of OCD.

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《Psychological medicine》 |2022年第14期|3267-3279|共13页
作者
MattiCervin; Euripedes C.Miguel; Ay?egül SelcenGülerYgor A.Ferr?oAy?e BurcuErdo?duLuisaLazaroSeblaG?k?eDaniel A.GellerYaseminYulaf?aziye SenemBa?gül?zlem?zcanKorayKarabekiro?luLeonardo F.FontenelleYank?YazganEric A.StorchJames F.LeckmanMaria Concei??odo RosárioDavidMataix-Cols;
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作者单位

Lund University;

Universidade de Sao Paulo;

Beykent UniversityPorto Alegre Health Sciences Federal UniversityMarmara UniversityHospital Clínic, IDIBAPS, CIBERSAM, University of BarcelonaMaltepe UniversityMassachusetts General Hospital, Harvard Medical SchoolGeli?im UniversityHasan Kalyoncu University?n?nü UniversityOndokuz May?s UniversityTurner Institute for Brain and Mental Health, Monash UniversityGüzel Günler ClinicBaylor College of MedicineChild Study Center, Yale UniversityFederal University of S?o Paulo (UNIFESP)Centre for Psychiatry Research, Karolinska Institutet;

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正文语种英语
中图分类医学心理学、病理心理学;
关键词
Obsessive–compulsive disorder; symptom dimensions; heterogeneity; factor analysis; network analysis;

Towards a definitive symptom structure of obsessive?compulsive disorder: a factor and network analysis of 87 distinct symptoms in 1366 individuals

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