Biocompatibility of an apical ring plug for left ventricular assist device explantation: Results of a feasibility pre‐clinical study

Silvia Mariani; Tong Li; Jan HegermannKarl BounaderJasmin HankeTanja MeyerHeike Jannsen‐PetersAxel HaverichJan D. SchmittoGünes Dogan

首页> 外文期刊>Artificial Organs >Biocompatibility of an apical ring plug for left ventricular assist device explantation: Results of a feasibility pre‐clinical study

【24h】

Biocompatibility of an apical ring plug for left ventricular assist device explantation: Results of a feasibility pre‐clinical study

机译：Biocompatibility of an apical ring plug for left ventricular assist device explantation: Results of a feasibility pre‐clinical study

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Abstract Background Patients receiving left ventricle assist devices (LVADs) as bridge to recovery remain a minority with 1%–5% of LVADs explanted after improvement of myocardial function. Nevertheless, considering the growing population of patients supported with LVADs, an increasing demand of new explantation strategies is expected in the near future. A novel plug for LVAD explantation has been developed and its biocompatibility profile needs to be proved. This study tested the biocompatibility of this novel plug in an in vivo ovine model. Methods Six adult Blackhead Persian female sheep received plug implantation on the cardiac apex via minimally invasive approach and were clinically observed up to 90?days. Echocardiography was performed to detect thrombus formation or further plug‐related complications. After the observation period, euthanasia was performed and samples including the plug and the surrounding tissues were obtained to be analyzed with correlative light and electron microscopy. Organ necrosis, ischemia and peripheral embolism were investigated. Results Three animals survived surgery and completed the follow‐up time without experiencing clinical complications. Echocardiographic controls excluded the presence of an intracavitary thrombus in the left ventricle (LV). Autopsy confirmed no signs of local infection, LV thrombus or peripheral embolism. Light and electron microscopy revealed an intact epithelium covering a layer of connective tissue on the plug surface facing the heart lumen. Conclusions This novel apical plug for LVAD explantation allows for endothelial and connective tissue growth on its ventricular side within 90?days from surgery. Further studies are required to fully demonstrate the biocompatibility of this apical plug and investigate the optimal anticoagulation regimen to be applied after implantation.

著录项

来源
《Artificial Organs》 |2022年第5期|827-837|共11页
作者
Silvia Mariani; Tong Li; Jan HegermannKarl BounaderJasmin HankeTanja MeyerHeike Jannsen‐PetersAxel HaverichJan D. SchmittoGünes Dogan;
展开▼
作者单位

Department of Cardiothoracic, Transplantation and Vascular Surgery,Hannover Medical School;

Institute of Functional and Applied Anatomy, Research Core Unit Electron Microscopy,Hannover;

Division of Cardiothoracic and Vascular Surgery,Pontchaillou University HospitalMedimplant GmbH;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类器官移植术;
关键词
apical ring plug; correlative light and electron microscopy; heart failure; left ventricle assist device; LVAD explantation; myocardial recovery;

Biocompatibility of an apical ring plug for left ventricular assist device explantation: Results of a feasibility pre‐clinical study

摘要

著录项

相关主题

期刊订阅