Associations of Autism Spectrum Disorder with PM25 Components: A Comparative Study Using Two Different Exposure Models

Md Mostafijur Rahman; Sarah A. Carter; Jane C. Lin

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Associations of Autism Spectrum Disorder with PM25 Components: A Comparative Study Using Two Different Exposure Models

机译：Associations of Autism Spectrum Disorder with PM25 Components: A Comparative Study Using Two Different Exposure Models

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This retrospective cohort study examined associations of autism spectrum disorder (ASD) with prenatal exposure to major fine particulate matter (PM2S) components estimated using two independent exposure models. The cohort included 318 750 mother—child pairs with singleton deliveries in Kaiser Permanente Southern California hospitals from 2001 to 2014 and followed until age five. ASD cases during follow-up (N = 4559) were identified by ICD codes. Prenatal exposures to PM2S, elemental (EC) and black carbon (BC), organic matter (OM), nitrate (N03~), and sulfate (SOj~) were constructed using (i) a source-oriented chemical transport model and (ii) a hybrid model. Exposures were assigned to each maternal address during the entire pregnancy, first, second, and third trimester. In single-pollutant models, ASD was associated with pregnancy-average PM2S, EC/BC, OM, and SO-exposures from both exposure models, after adjustment for covariates. The direction of effect estimates was consistent for EC/BC and OM and least consistent for N03~. EC/BC, OM, and SO2- were generally robust to adjustment for other components and for PM2S. EC/BC and OM effect estimates were generally larger and more consistent in the first and second trimester and SO - in the third trimester. Future PM25 composition health effect studies might consider using multiple exposure models and a weight of evidence approach when interpreting effect estimates.

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《Environmental Science & Technology: ES&T》 |2023年第1期|405-414|共10页
作者
Md Mostafijur Rahman; Sarah A. Carter; Jane C. Lin;
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作者单位

Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California 90032, United States;

Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, California 91101, United States;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
PM2Sl PM2i chemical components; autism spectrum disorders; prenatal exposures; exposure models;

Associations of Autism Spectrum Disorder with PM25 Components: A Comparative Study Using Two Different Exposure Models

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