Molecular and metabolic heterogeneity of astrocytes and microglia

Hasel Philip; Aisenberg William H.; Bennett F. ChrisLiddelow Shane A.

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Molecular and metabolic heterogeneity of astrocytes and microglia

机译：Molecular and metabolic heterogeneity of astrocytes and microglia

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摘要

Astrocytes and microglia are central players in a myriad of processes in the healthy and diseased brain, ranging from metabolism to immunity. The crosstalk between these two cell types contributes to pathology in many if not all neuroinflammatory and neurodegenerative diseases. Recent advancements in integrative multimodal sequencing techniques have begun to highlight how heterogeneous both cell types are and the importance of metabolism to their regulation. We discuss here the transcriptomic, metabolic, and func-tional heterogeneity of astrocytes and microglia and highlight their interaction in health and disease.

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《Cell metabolism》 |2023年第4期|555-570|共16页
作者
Hasel Philip; Aisenberg William H.; Bennett F. ChrisLiddelow Shane A.;
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作者单位

New York University,NYU;

University of Pennsylvania,Univ Penn;

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原文格式 PDF
正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
IN-VITRO; MONOCARBOXYLATE TRANSPORTERS; ASTROGLIAL CELLS; BRAIN; MOUSE; CHOLESTEROL; NEURONS; EXPRESSION; CLEARANCE; REVEALS;

Molecular and metabolic heterogeneity of astrocytes and microglia

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