Commentary on 'Dysfunctional dendritic cells limit antigen-specific T cell response in glioma'

Robert M. Prins; Richard G. Everson

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Commentary on 'Dysfunctional dendritic cells limit antigen-specific T cell response in glioma'

机译：Commentary on 'Dysfunctional dendritic cells limit antigen-specific T cell response in glioma'

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In this issue of Neuro-Oncology, Friedrich et al. from the German Cancer Research Center in Heidelberg, Germany, investigate the importance of conventional dendritic cell (cDC) subsets to anti-tumor immunity and compare their pheno-typic and functional differences between IDH-mutant and IDH wild type tumors in preclinical models. The importance of these cDC in anti-tumor immunity have been proven in other extracranial tumors in recent years. cDC1 are now known to be critical for the cross-presentation of tumor antigens, and loss of this unique cDC population is directly related to substantial deficiency for mice to reject transplant-able tumors. Little is known about the immunological relevance of these cDC populations in gliomas. Although, recent findings from the single cell RNA-seq of recurrent glioblas-toma (GBM) patients treated with neoadjuvant Programmed Death 1 (PD-1) immune checkpoint blockade suggests that the local activation ofT cells within the tumor microenviron-ment activates a chemokine axis by which cDC are recruited into the tumors of these patients, highlighting the central role cDC play.

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《Neuro-oncology》 |2023年第2期|277-278|共2页
作者
Robert M. Prins; Richard G. Everson;
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Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA, Jonsson Comprehensive Cancer Center, Da;

Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA;

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Commentary on 'Dysfunctional dendritic cells limit antigen-specific T cell response in glioma'

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