EFFECTS OF SILVER NITRATE NANOPARTICLES ON THE OXIDATIVE STATUS IN SPRAGUE DAWLEY RATS

ESRAA M. FAHMY; SHARKAWY A.A.; IBRAHEIM TH.A.DOHA YAHIA

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EFFECTS OF SILVER NITRATE NANOPARTICLES ON THE OXIDATIVE STATUS IN SPRAGUE DAWLEY RATS

机译：EFFECTS OF SILVER NITRATE NANOPARTICLES ON THE OXIDATIVE STATUS IN SPRAGUE DAWLEY RATS

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This study investigated the toxic effects of silver nanoparticles (8.67-26.3 nm) on body weight, organs body weight ratio and oxaditive status of male Sprague Dawley rats over a period of three months. In this experimental study, 100 male Sprague Dawley rats were categorized in four groups including control group and three experimental groups (n=25 in each group). The rats in the experimental groups were orally intubated 5 mg/kg, 25 mg/kg and 50 mg/kg of AgNPs solution by gavage, five days a week. Samples of blood were taken from the rats for oxidative stress assessments. Afterwards, lungs, kidney, liver and brain removed and weighted to calculate organs body weight ratio. The results demonstrated a statistically no significant change in final body weight nor organs relative weight %, oxidative stress condition were investigated with increase MDA level and decrease SOD, CAT and TAC level in serum.

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《Assiut Veterinary Medical Journal》 |2020年第164期|85-91|共7页
作者
ESRAA M. FAHMY; SHARKAWY A.A.; IBRAHEIM TH.A.DOHA YAHIA;
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作者单位

Dept. of Forensic Medicine and Toxicology, Fac. Vet. Medicine, Sohag University;

Dept. of Forensic Medicine and Toxicology, Fac. Vet. Medicine, Assiut University;

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正文语种英语
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Silver nano-particles; body weight; malondialdhyde; catalase; total antioxidants capacity;

EFFECTS OF SILVER NITRATE NANOPARTICLES ON THE OXIDATIVE STATUS IN SPRAGUE DAWLEY RATS

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