Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

Verma V.; Bordignon S.; Chierotti M.R.Lestari M.Lyons K.Padrela L.Ryan K.M.Lusi M.

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Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

机译：Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

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Multidrug products enable more effective therapies and simpler administration regimens, provided that a stable formulation is prepared, with the desired composition. In this view, solid solutions have the advantage of combining the stability of a single crystalline phase with the potential of stoichiometry variation of a mixture. Here a drug–prodrug solid solution of cortisone and cortisol (hydrocortisone) is described. Despite the structural differences of the two components, the new phase is obtained both from solution and by supercritical CO2 assisted spray drying. In particular, to enter the solid solution, hydrocortisone must violate Etter's rules for hydrogen bonding. As a result, its dissolution rate is almost doubled.

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来源
《iucrj》 |2020年第6期|1124-1130|共7页
作者
Verma V.; Bordignon S.; Chierotti M.R.Lestari M.Lyons K.Padrela L.Ryan K.M.Lusi M.;
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作者单位

Department of Chemistry and Bernal Institute, University of Limerick;

Dipartimento di Chimica, Università di Torino;

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正文语种英语
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关键词
SOLID SOLUTIONS; MIXED CRYSTALS; MULTIDRUG FORMULATIONS; STEROIDS; PHARMACEUTICAL SOLIDS; ASSISTED SPRAY DRYING; HYDROGEN BONDING; HYDROCORTISONE; CORTISONE;

Cortisone and cortisol break hydrogen-bonding rules to make a drug–prodrug solid solution

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