Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

Le Minh Patrick; Le Hingrat Quentin; Jaquet PierreWicky Paul-HenriBunel VincentMassias LaurentVisseaux BenoitMessika JonathanDescamps DianeMal HerveTimsit Jean-FrancoisPeytavin Gilles

首页> 外文期刊>Antimicrobial agents and chemotherapy. >Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

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Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

机译：Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

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Remdesivir has reported efficacy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and in vivo. Drug-drug interactions limit therapeutic options in transplant patients. Remdesivir and its metabolite GS-441524 are excreted principally in urine. In intensive care unit (ICU) settings, in which multiple-organ dysfunctions can occur rapidly, hemodialysis may be a viable option for maintaining remdesivir treatment, while improving tolerance, by removing both remdesivir's metabolite (GS-441524) and sulfobutylether beta-cyclodextrin sodium (SEBCD). Additional studies may prove informative, particularly in the evaluations of therapeutic options for coronavirus disease 2019 (COVID-19).

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来源
《Antimicrobial agents and chemotherapy.》 |2020年第11期|共4页
作者
Le Minh Patrick; Le Hingrat Quentin; Jaquet PierreWicky Paul-HenriBunel VincentMassias LaurentVisseaux BenoitMessika JonathanDescamps DianeMal HerveTimsit Jean-FrancoisPeytavin Gilles;
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作者单位

Bichat Claude Bernard Hosp, AP HP, Virol Dept, Paris, France;

Bichat Claude Bernard Hosp, AP HP, Pneumol B & Lung Transplant Dept, INSERM 1152, Paris, France;

Bichat Claude Bernard Hosp, AP HP, Pharmacol Toxicol Dept, Paris, FranceBichat Claude Bernard Hosp, AP HP, Med & Infect Dis ICU MI2, Paris, FranceUniv Paris, INSERM, IAME, UMRS 1137, Paris, France;

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原文格式 PDF
正文语种英语
中图分类治疗学;
关键词
hemodialysis; pharmacokinetics; remdesivir;

Removal of Remdesivir's Metabolite GS-441524 by Hemodialysis in a Double Lung Transplant Recipient with COVID-19

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