Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

Xu Xue; Hao Zhang; Han LiuSicheng WangJiadong LiQirong ZhouXiao ChenXiaoxiang RenYingying JingYonghui DengZhen GengXiuhui WangJiacan Su

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Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

机译：Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

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3D-printed polycaprolactone (PCL) scaffolds have been extensively studiedfor application in bone tissue engineering. However, PCL-based scaffoldswith enhanced bioactivity and intelligent delivery capability for bone repairremains challenging. Herein, CuS nanoparticle-PEG soft hydrogel-coated3D hard polycaprolactone scaffolds (denoted as CuS-PEG-PCL scaffold)are rationally designed for efficient bone regeneration. CuS nanoparticlescross-linked PEG hydrogel (CuS-PEG-hydrogel) endows the PCL-basedscaffold with excellent photothermal properties and stable soft elasticity,while the PCL scaffold provides excellent mechanical performance. Uponexposure to 1064 nm near-infrared (NIR) light irradiation, dexamethasonesodium phosphate (Dexp), stored in the CuS-PEG-PCL scaffold, can becontrollably released, which efficiently promotes osteogenic differentiationof bone mesenchymal stem cells (BMSCs). In addition, the combination ofmild heating at 42 ± 0.5 ℃ further promoted osteogenic differentiationof BMSCs. Subsequently, this Dexp-loaded CuS-PEG-PCL scaffold(D-CuS-PEG-PCL scaffold) with NIR light treatment at the tibial defectof rats presented the highest bone regeneration capacity. These findingsdemonstrate that the Dexp-loaded CuS-PEG-hydrogel can effectively modifythe 3D printed PCL scaffold. Therefore, this multifunctional scaffold witha soft-hard hybrid structure has the potential to become an advanced drugdelivery vehicle in the treatment of large bone defects.

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《Advanced functional materials》 |2022年第33期|2202470.1-2202470.14|共14页
作者
Xu Xue; Hao Zhang; Han LiuSicheng WangJiadong LiQirong ZhouXiao ChenXiaoxiang RenYingying JingYonghui DengZhen GengXiuhui WangJiacan Su;
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Institute of Translational MedicineShanghai UniversityShanghai 200444, P. R. China;

Department of Orthopaedics TraumaChanghai HospitalSecond Military Medical UniversityShanghai 200433, P. R. China;

Department of Chemistry and State Key Laboratory of MolecularEngineering of PolymersFudan UniversityShanghai 200433, P. R. ChinaInstitute of Translational MedicineShanghai UniversityShanghai 200444, P. R. China;

Department of Orthopaedics TraumaChanghai HospitalSecond Military Medical UniversityShanghai 200433, P. R. China;

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bone regeneration; controlled drug release; CuS nanoparticles; photothermal therapy; polycaprolactone scaffolds;

Rational Design of Multifunctional CuS Nanoparticle-PEG Composite Soft Hydrogel-Coated 3D Hard Polycaprolactone Scaffolds for Efficient Bone Regeneration

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