Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation

Tingting Hu; Weicheng Shen; Fanqi MengShuqing YangShilong YuHai LiQinghua ZhangLin GuChaoliang TanRuizheng Liang

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Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation

机译：Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation

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Sonodynamic therapy (SDT) has been a promising therapeutic modality forcancer because of its superior advantages compared with other therapeuticstrategies. However, the current sonosensitizers used for SDT normallyexhibit low activity for ultrasound (US)-induced reactive oxygen species(ROS) generation. Herein, the crystalline-to-amorphous phase transformationis reported as a simple but powerful strategy to engineer ultrathin 2DCoW-LDH and NiW-LDH nanosheets as highly efficient sonosensitizers forSDT. The phase transformation of CoW-LDH and NiW-LDH nanosheets frompolycrystalline to amorphous ones is achieved through a simple acid etchingtreatment. Importantly, compared with the polycrystalline one, the amorphousCoW-LDH (a-CoW-LDH) nanosheets possess higher ROS generationactivity under US irradiation, which is ≈17 times of the commercial TiO_2 sonosensitizer.The results suggest that the enhanced performance of ultrathina-CoW-LDH nanosheets for US-induced ROS generation may be attributed tothe phase transformation-induced defect generation and electronic structurechanges. After polyethylene glycol modification, the a-CoW-LDH nanosheetscan serve as a high-efficiency sonosensitizer for SDT to achieve cell death invitro and tumor eradication in vivo under US irradiation.

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《Advanced Materials》 |2023年第17期|2209692.1-2209692.11|共11页
作者
Tingting Hu; Weicheng Shen; Fanqi MengShuqing YangShilong YuHai LiQinghua ZhangLin GuChaoliang TanRuizheng Liang;
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作者单位

State Key Laboratory of Chemical Resource EngineeringBeijing Advanced Innovation Center for Soft Matter Scienceand EngineeringBeijing University of Chemical TechnologyBeijing 100029, P. R. China;

Beijing National Laboratory for Condensed Matter PhysicsInstitute of PhysicsChinese Academy of SciencesBeijing 100190, P. R. China;

Institute of Advanced Materials (IAM) and Key Laboratoryof Flexible Electronics (KLoFE)Nanjing Tech University (NanjingTech)30 South Puzhu Road, Nanjing 211816, P. R. ChinaSchool of Materials Science and EngineeringTsinghua UniversityBeijing 100084, P. R. ChinaDepartment of Chemistry and Center of Super-Diamondand Advanced Films (COSDAF)City University of Hong KongKowloon, Hong Kong SAR 999077, P. R. China,Shenzhen Research InstituteCity University of Hong KongShenzhen 518057, P. R. China;

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2D nanosheets; layered double hydroxides; phase transformation; sonodynamic therapy; sonosensitizers;

Boosting the Sonodynamic Cancer Therapy Performance of 2D Layered Double Hydroxide Nanosheet-Based Sonosensitizers Via Crystalline-to-Amorphous Phase Transformation

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