Ability of S100B to predict post-concussion syndrome in paediatric patients who present to the emergency department with mild traumatic brain injury

Kelmendi Fatos M.; Morina Arsim A.; Mekaj Agon Y.Dragusha ShefkiAhmeti FetiAlimehmeti RidvanMorina QamileBerisha MuratKrasniqi BlerimKerolli Berat

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Ability of S100B to predict post-concussion syndrome in paediatric patients who present to the emergency department with mild traumatic brain injury

机译：Ability of S100B to predict post-concussion syndrome in paediatric patients who present to the emergency department with mild traumatic brain injury

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Introduction Among children who sustain mild traumatic brain injury (mTBI), 10-30% develop a cluster of cognitive, physical, and emotional symptoms commonly referred to as post-concussion syndrome (PCS). Symptoms typically resolve within 7-10 days, but a minority of patients report symptoms that persist for months or even years. The aim of our study was to identify a neurobiochemical marker after mTBI that can predict the presence of post-concussion syndrome three months after head injury in paediatric patients. Materials and methods Children between 7 and 16 years of age who had head trauma and no other complaints were included. Three months after the initial visit, participants or parents/guardians were interviewed in person about the children's PCS symptoms using the Rivermead Post-Concussion Symptoms Questionnaire (RPQ). Results The mean value of S100B protein in serum in 38 patients without signs of PCS was 0.266 mu g L-1, with a 95% confidence interval (CI) of 0.221 - 0.310 mu g L-1. Among the 22 patients with signs of PCS, the mean value of S100B protein in serum was 0.845 mu g L-1, with a 95% CI of 0.745-0.945 mu g L-1. Patients with signs of PCS had higher S100B protein levels than those without signs of PCS (p < 0.0001). Conclusions Our prospective study showed that S100B protein is a useful neurobiomarker for detecting paediatric patients at risk for post-concussion syndrome. We found that the biomarker S100B correlated with the severity of traumatic brain injury (number of lesions on CT) and the presence of post-concussion syndrome.

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《British journal of neurosurgery》 |2023年第1期|53-58|共6页
作者
Kelmendi Fatos M.; Morina Arsim A.; Mekaj Agon Y.Dragusha ShefkiAhmeti FetiAlimehmeti RidvanMorina QamileBerisha MuratKrasniqi BlerimKerolli Berat;
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作者单位

Fac Med,Univ Prishtina;

Serv Neurosurg,Univ Hosp Ctr Mother Teresa;

Clin Anaesthesiol,Univ Clin Ctr KosovoClin Paediat Surg,Univ Clin Ctr KosovoColl Med Sci REZONANCA Gllokute Shelgjet Vetern;

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正文语种英语
中图分类头部及神经外科学;
关键词
Post-concussion syndrome; mild traumatic brain injury; head CT; paediatric population; HEAD-INJURY; STATEMENT; CONSENSUS; SYMPTOMS; PROTEIN;

Ability of S100B to predict post-concussion syndrome in paediatric patients who present to the emergency department with mild traumatic brain injury

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