• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Autism research : >Region‐specific associations between gamma‐aminobutyric acid A receptor binding and cortical thickness in high‐functioning autistic adults
【24h】

Region‐specific associations between gamma‐aminobutyric acid A receptor binding and cortical thickness in high‐functioning autistic adults

机译：Region‐specific associations between gamma‐aminobutyric acid A receptor binding and cortical thickness in high‐functioning autistic adults

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Abstract The neurobiology of autism has been shown to involve alterations in cortical morphology and gamma‐aminobutyric acid A (GABAA) receptor density. We hypothesized that GABAA receptor binding potential (GABAAR BPND) would correlate with cortical thickness, but their correlations would differ between autistic adults and typically developing (TD) controls. We studied 50 adults (23 autism, 27 TD, mean age of 27?years) using magnetic resonance imaging to measure cortical thickness, and [18F]flumazenil positron emission tomography imaging to measure GABAAR BPND. We determined the correlations between cortical thickness and GABAAR BPND by cortical lobe, region‐of‐interest, and diagnosis of autism spectrum disorder (ASD). We also explored potential sex differences in the relationship between cortical thickness and autism characteristics, as measured by autism spectrum quotient (AQ) scores. Comparing autism and TD groups, no significant differences were found in cortical thickness or GABAAR BPND. In both autism and TD groups, a negative relationship between cortical thickness and GABAAR BPND was observed in the frontal and occipital cortices, but no relationship was found in the temporal or limbic cortices. A positive correlation was seen in the parietal cortex that was only significant for the autism group. Interestingly, in an exploratory analysis, we found sex differences in the relationships between cortical thickness and GABAAR BPND, and cortical thickness and AQ scores in the left postcentral gyrus. Lay Summary The thickness of the brain cortex and the density of the receptors associated with inhibitory neurotransmitter GABA have been hypothesized to underlie the neurobiology of autism. In this study, we found that these biomarkers correlate positively in the parietal cortex, but negatively in the frontal and occipital cortical regions of the brain. Furthermore, we collected preliminary evidence that the correlations between cortical thickness and GABA receptor density are sexdependent in a brain region where sensory inputs are registered.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号