Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicine

Zhang Yonggang; Li Jiaping; Soleimani MohammadGiacomini FrancescaFriedrich HeinerTruckenmuller RomanHabibovic Pamela

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Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicine

机译：Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicine

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Biodegradable porous calcium phosphate (CaP) ceramics are widely used as synthetic graft substitutes for bone regeneration, owing to their chemical and structural similarity to bone and associated bioactivity in terms of bone-bonding, osteoconductive, and even osteoinductive properties. Nevertheless, the intrinsic brittleness and poor processability of porous CaP ceramics strongly impair their clinical applicability. Herein, a biphasic calcium phosphate (BCP) sponge is developed that consists of a self-supporting network of seamlessly interwoven hydroxyapatite nanowires and beta-tricalcium phosphate nanofibers and possesses a highly interconnected porous structure with open cell geometry and ultrahigh porosity. Owing to its unique properties, the ceramic sponge can be easily processed into various shapes and dimensions, such as cylindrical scaffolds and thin, flexible membranes. Moreover, the BCP sponge can be introduced into a bone defect in a compacted or folded state from a syringe and, upon wetting, expand to its original shape, thereby filling the cavity. The nanofibrous sponge gradually degrades in vitro and rapidly mineralizes when immersed in simulated body fluid. Moreover, it adsorbs significantly more proteins than a conventional porous BCP ceramic. Finally, the nanofibrous sponge supports the attachment, proliferation, and osteogenic differentiation of human mesenchymal stromal cells comparable to the conventional porous BCP ceramic.

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《Advanced functional materials》 |2021年第40期|2102911.1-2102911.12|共12页
作者
Zhang Yonggang; Li Jiaping; Soleimani MohammadGiacomini FrancescaFriedrich HeinerTruckenmuller RomanHabibovic Pamela;
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作者单位

Maastricht Univ, Dept Instruct Biomat Engn, MERLN Inst Technol Inspired Regenerat Med, Univ Singel 40, NL-6229 ER Maastricht, Netherlands;

Maastricht Univ, Dept Instruct Biomat Engn, MERLN Inst Technol Inspired Regenerat Med, Univ Singel 40, NL-6229 ER Maastricht, Netherlands|Maastricht Univ, Dept Complex Tissue Regenerat, MERLN Inst Technol Inspired Regenerat Med, Univ Singel 40, NL-6229 ER;

Eindhoven Univ Technol, Lab Phys Chem, Dept Chem Engn & Chem, Greene Loper 5, NL-5612 AE Eindhoven, Netherlands|Eindhoven Univ Technol, Ctr Multiscale Electron Microscopy, Dept Chem Engn & Chem, Greene Loper 5, NL-5612 AE Eindhoven, Netherlands|Eindhoven Eindhoven Univ Technol, Lab Phys Chem, Dept Chem Engn & Chem, Greene Loper 5, NL-5612 AE Eindhoven, Netherlands|Eindhoven Univ Technol, Ctr Multiscale Electron Microscopy, Dept Chem Engn & Chem, Greene Loper 5, NL-5612 AE Eindhoven, Netherlands;

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正文语种英语
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calcium phosphate; elasticity; nanofibers; processability; shape memory;

Biodegradable Elastic Sponge from Nanofibrous Biphasic Calcium Phosphate Ceramic as an Advanced Material for Regenerative Medicine

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