Synthetic Gene Circuits: Design, Implement, and Apply

Andrew Lezia; Arianna Miano; Jeff Hasty

首页> 外文期刊>Proceedings of the IEEE >Synthetic Gene Circuits: Design, Implement, and Apply

【24h】

Synthetic Gene Circuits: Design, Implement, and Apply

机译：Synthetic Gene Circuits: Design, Implement, and Apply

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Synthetic biologists engineered the first genetic toggle switch and clock at the turn of the 21st century. Since the development of these first gene circuits, methods for circuit design and construction have improved dramatically, narrowing the gap between concept and proof-of-principle implementation. Engineered genetic constructs have started to leave the lab for the real world where they are being used in applications, including medicine, biosensing, and industrial chemical production. The field of synthetic gene circuits has also grown from focusing on single, isolated circuits to designing complex systems that operate across multiple populations in carefully engineered consortia. In addition, design methods have progressively moved toward including detailed models of the interactions between the host genome and the synthetic gene circuits that it contains in order to better predict circuit dynamics. This article will review some of the most recent advances in gene circuit design and implementation, with a focus on synthetic gene circuits being applied to address real-world problems.

著录项

来源
《Proceedings of the IEEE》 |2022年第5期|613-630|共18页
作者
Andrew Lezia; Arianna Miano; Jeff Hasty;
展开▼
作者单位

University of California at San Diego;

BioCircuits Institute, University of California at San Diego;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类电工技术;自动化技术、计算机技术;
关键词
Computational design; genetic engineering; synthetic biology; synthetic gene circuits; Genetics; Circuit synthesis; Logic gates; Integrated circuit modeling; Mathematical models; Biology; Proteins;

Synthetic Gene Circuits: Design, Implement, and Apply

摘要

著录项

相关主题

期刊订阅