An Increasing Threat in an Iranian Referral Children's Hospital: Multidrug-Resistant Acinetobacter baumannii

Babak Pourakbari; Shima Mahmoudi; Reza HabibiMohammad Taghi Haghi AshtianiReihaneh Hosseinpour SadeghiMahmoud KhodabandehSetareh Mamishi

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An Increasing Threat in an Iranian Referral Children's Hospital: Multidrug-Resistant Acinetobacter baumannii

机译：An Increasing Threat in an Iranian Referral Children's Hospital: Multidrug-Resistant Acinetobacter baumannii

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Introduction: Acinetobacter baumannii has emerged as an important nosocomialpathogen in the past decades. Due to the prevalence of A. baumannii acrossthe world, suitable typing methods to investigate the epidemiological distribution ofthe organism have been developed. The aim of this study was to investigate the epidemiologicaland molecular diversity of A. baumannii strains isolated from nosocomialinfections of hospitalized children in Children Medical Center Hospital(CMC), an Iranian referral hospital, in Tehran, Iran.Material and Methods: A total of 27 non-duplicate clinical A. baumannii isolateswere collected during October 2013 to March 2014 and tested for antimicrobial resistanceto several antibiotic agents. The genetic similarity of the strains was investigatedby amplification of Random amplified polymorphic DNA-polymerase chainreaction (RAPD-PCR) method.Results: One predominant RAPD profile (type B) was identified in 15 strains (56%of all typed isolates). Other clusters depicted in the dendrogram, namely A, C, and Dcomprised 6 (22%), 5 (19%) and 1 (3%) isolates, respectively. All A. baumanniistrains were resistant to all antibiotics except colistin.Conclusion: This study highlights the clonal spread of multidrug-resistant A. baumanniiin our hospital. Therefore, the factors responsible for dissemination of suchisolates need to be identified, controlled, and prevented to avoid major outbreaks.

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《Infectious disorders drug targets》 |2018年第2期|129-135|共7页
作者
Babak Pourakbari; Shima Mahmoudi; Reza HabibiMohammad Taghi Haghi AshtianiReihaneh Hosseinpour SadeghiMahmoud KhodabandehSetareh Mamishi;
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作者单位

Department of Pathology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;

Pediatric Infectious Disease Research Center, Tehran University of Medical Science, Tehran, Iran;

Department of Infectious Diseases, Pediatrics Center of Excellence, Children`s Medical Center;

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正文语种英语
中图分类药学;
关键词
A. baumannii; antimicrobial resistance; genotyping; RAPD profile; isolates organism;

An Increasing Threat in an Iranian Referral Children's Hospital: Multidrug-Resistant Acinetobacter baumannii

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