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Associations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development

机译：Associations of maternal urinary bisphenol and phthalate concentrations with offspring reproductive development

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摘要

? 2022 The AuthorsFetal exposure to bisphenols and phthalates may influence development of the reproductive system. In a population-based, prospective cohort study of 1059 mother-child pairs, we examined the associations of maternal gestational urinary bisphenols and phthalates concentrations with offspring reproductive development from infancy until 13 years. We measured urinary bisphenol and phthalate concentrations in each trimester. We obtained information on cryptorchidism or hypospadias after birth from medical records. At 9.7 years, we measured testicular and ovarian volume by MRI. At 13.5 years, we measured child Tanner stages and menstruation through questionnaire. We performed linear or logistic regression models for boys and girls to assess the associations of maternal urinary average and trimester-specific bisphenols and phthalates with child reproductive outcomes. Next, to further explore potential synergistic or additive effects of exposures together, we performed mixed exposure models using a quantile g computation approach. Models were adjusted for maternal age, ethnicity, body-mass index, education, parity, energy intake, smoking and alcohol use, and child's gestational age at birth, birthweight and body-mass index. In boys, no associations of maternal gestational phthalate or bisphenol with offspring cryptorchidism and hypospadias were found. Higher maternal high-molecular-weight phthalate and total bisphenol, but not phthalic acid or low-molecular-weight phthalate, were associated with larger child testicular volume at 10 years. Higher maternal phthalic acid and total bisphenol were associated with earlier genital and pubic hair development at 13 years, respectively (p-values<0.05). In girls, we found no associations of maternal urinary bisphenol and phthalate with ovarian volume or menstrual age. Only higher maternal urinary high-molecular-weight phthalate was associated with earlier pubic hair development at 13 years (p-values <0.05). Higher mixture exposure was associated with earlier pubic hair development in both sexes. In conclusion, higher maternal gestational urinary bisphenol and phthalate concentrations were associated with alterations in offspring reproductive development, mainly in boys.

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  • 来源
    《Environmental Pollution》 |2022年第9期|1-11|共11页
  • 作者

    Blaauwendraad S.M.; Jaddoe V.W.; Santos S.Gaillard R.Kannan K.Trasande L.Dohle G.R.;

  • 作者单位

    The Generation R Study Group Erasmus MC University Medical Center||Department of Pediatrics Erasmus MC University Medical Center;

    The Generation R Study Group Erasmus MC University Medical CenterThe Generation R Study Group Erasmus MC University Medical Center||Department of Pediatrics Erasmus MC University Medical Center;

    ||Department of Paediatrics New York University School of Medicine||Department of Environmental Medicine New York University School of MedicineDepartment of Paediatrics New York University School of Medicine||Department of Environmental Medicine New York University School of Medicine||Department of Population Health New York University School of Medicine||New York University Wagner School of PubDepartment of Urology Erasmus MC University Medical Center;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
  • 原文格式 PDF
  • 正文语种 英语
  • 中图分类
  • 关键词

    Bisphenols; Phthalates; Pregnancy; Puberty; Reproductive development;

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