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Engineering of a plant-produced virus-like particle to improve the display of the Plasmodium falciparum Pfs25 antigen and ransmission-blocking activity of the vaccine candidate

机译：Engineering of a plant-produced virus-like particle to improve the display of the Plasmodium falciparum Pfs25 antigen and ransmission-blocking activity of the vaccine candidate

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Malaria kills around 409,000 people a year, mostly children under the age of five. Malaria transmissionblocking vaccines work to reduce malaria prevalence in a community and have the potential to be part of a multifaceted approach required to eliminate the parasites causing the disease. Pfs25 is a leading malaria transmission-blocking antigen and has been successfully produced in a plant expression system as both a subunit vaccine and as a virus-like particle. This study demonstrates an improved version of the viruslike particle antigen display molecule by eliminating known protease sites from the prior A85 variant. This re-engineered molecule, termed B29, displays three times the number of Pfs25 antigens per viruslike particle compared to the original Pfs25 virus-like particle. An improved purification scheme was also developed, resulting in a substantially higher yield and improved purity. The molecule was evaluated in a mouse model and found to induce improved transmission-blocking activity at lower doses and longer durations than the original molecule.

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