QUANTITATIVE ASSESSMENT OF AUTOMATED OPTICAL COHERENCE TOMOGRAPHY IMAGE ANALYSIS USING A HOME-BASED DEVICE FOR SELF-MONITORING NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

Jonathan D.Oakley; StevenVerdooner; Daniel B.RussakoffAlexander J.BruckerJohnSeamanJayashreeSahniCarlo D.BIANCHIMarianoCozziJohnRogersGiovanniStaurenghi

首页> 外文期刊>Retina >QUANTITATIVE ASSESSMENT OF AUTOMATED OPTICAL COHERENCE TOMOGRAPHY IMAGE ANALYSIS USING A HOME-BASED DEVICE FOR SELF-MONITORING NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

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QUANTITATIVE ASSESSMENT OF AUTOMATED OPTICAL COHERENCE TOMOGRAPHY IMAGE ANALYSIS USING A HOME-BASED DEVICE FOR SELF-MONITORING NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

机译：QUANTITATIVE ASSESSMENT OF AUTOMATED OPTICAL COHERENCE TOMOGRAPHY IMAGE ANALYSIS USING A HOME-BASED DEVICE FOR SELF-MONITORING NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

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To evaluate a prototype home optical coherence tomography device and automated analysis software for detection and quantification of retinal fluid relative to manual human grading in a cohort of patients with neovascular age-related macular degeneration. Patients undergoing anti-vascular endothelial growth factor therapy were enrolled in this prospective observational study. In 136 optical coherence tomography scans from 70 patients using the prototype home optical coherence tomography device, fluid segmentation was performed using automated analysis software and compared with manual gradings across all retinal fluid types using receiver-operating characteristic curves. The Dice similarity coefficient was used to assess the accuracy of segmentations, and correlation of fluid areas quantified end point agreement. Fluid detection per B-scan had area under the receiver-operating characteristic curves of 0.95, 0.97, and 0.98 for intraretinal fluid, subretinal fluid, and subretinal pigment epithelium fluid, respectively. On a per volume basis, the values for intraretinal fluid, subretinal fluid, and subretinal pigment epithelium fluid were 0.997, 0.998, and 0.998, respectively. The average Dice similarity coefficient values across all B-scans were 0.64, 0.73, and 0.74, and the coefficients of determination were 0.81, 0.93, and 0.97 for intraretinal fluid, subretinal fluid, and subretinal pigment epithelium fluid, respectively. Home optical coherence tomography device images assessed using the automated analysis software showed excellent agreement to manual human grading.

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《Retina》 |2023年第3期|433-443|共11页
作者
Jonathan D.Oakley; StevenVerdooner; Daniel B.RussakoffAlexander J.BruckerJohnSeamanJayashreeSahniCarlo D.BIANCHIMarianoCozziJohnRogersGiovanniStaurenghi;
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作者单位

Novartis Pharma AG, Basel, Switzerland;

and;

Eye Clinic, Department of Biomedical and Clinical Science, University of Milan, Milan, Italy.;

OCTHealth LLC, Sacramento, California;

Voxeleron LLC, Austin, Texas;

Perelman School of Medicine, Scheie Eye Institute, University of Pennsylvania, PhiladelphiaNovartis Pharmaceuticals Corporation, East Hanover, New Jersey;

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正文语种英语
中图分类眼科学;
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入库时间 2024-01-25 00:50:22

QUANTITATIVE ASSESSMENT OF AUTOMATED OPTICAL COHERENCE TOMOGRAPHY IMAGE ANALYSIS USING A HOME-BASED DEVICE FOR SELF-MONITORING NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

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