Pharmacological Diversity of Triazole Scaffolds: A Review

Ramalakshmi Natarajan; Yuvarani Kesavan; Amuthalakshmi SivaperumanArunkumar Subramani

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Pharmacological Diversity of Triazole Scaffolds: A Review

机译：Pharmacological Diversity of Triazole Scaffolds: A Review

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Background: Heterocyclic compounds possess a wide variety of roles in most fields of science, such as biochemistry, medicinal chemistry, veterinary products, agrochemicals, etc. Triazole, a heterocycle compound, serves as a building block for various compounds having multiple applications, mostly in medicine. Triazole is a five-membered ring containing compounds that occur in nature, found in several microorganisms, fungi, and marine organisms. The triazole nucleus is a boon for researchers with significant scope in the long-term. Triazole derivatives possess various pharmacological properties due to their ability to exert several non-covalent interactions, which can improve the solubility and the ability to bind to bimolecular targets. Objective: We focused on the structure-activity relationship of triazole derivatives possessing various biological activities such as antibacterial, antifungal, anticonvulsant, antidiabetic, antimalarial, analgesic, anti-inflammatory, antioxidant, antidepressant, antitubercular, anticancer, etc. Results: This study revealed the significance of certain substituents on triazole nuclei for different biological activities. Conclusion: From this, we conclude that the triazole nucleus will be a lead for further research on drug discovery.

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《Current bioactive compounds》 |2022年第10期|19-43|共25页
作者
Ramalakshmi Natarajan; Yuvarani Kesavan; Amuthalakshmi SivaperumanArunkumar Subramani;
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作者单位

Sathyabama Institute of Science and Technology,School of Pharmacy,Tamil Nadu,Chennai,India,;

The Tamil Nadu Dr. M.G.R. Medical Universit,Department of Pharmaceutical Chemistry, C.L.Baid Metha College of Pharmacy,Thoraipakkam, Chennai, Tamil Nadu,Chennai,India,;

The Tamil Nadu Dr. M.G.R. Medical University,Department of Pharmaceutical Chemistry, C.L.Baid Metha College of Pharmacy,Thoraipakkam, Chennai, Tamil Nadu,Chennai,India,;

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正文语种英语
中图分类药学;
关键词
Heterocyclic compounds; 1; 2; 3-triazole; 4-triazole; pharmacological activity; antifungal activity; antibacterial activity.;

Pharmacological Diversity of Triazole Scaffolds: A Review

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