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Glycopeptide-Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

机译：Glycopeptide-Based Multifunctional Hydrogels Promote Diabetic Wound Healing through pH Regulation of Microenvironment

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摘要

Excessive inflammation, bacterial infection, and blocked angiogenesis makediabetic wound healing challenging. Multifunctional wound dressings haveseveral advantages in diabetic wound healing. In addition, the pH regulationof the microenvironment is shown to be a key factor that promotes skinregeneration through cellular immune regulation. However, few reportshave focused on the development of functional dressings with the ability toregulate the pH microenvironment and promote diabetic wound healing. Thisstudy presents a novel approach for regulating the pH microenvironment ofdiabetic wound sites using a glycopeptide-based hydrogel consisting of modifiedhyaluronic acid and poly(6-aminocaproic acid). This hydrogel forms anetwork through Schiff base interactions and metal complexation, which suppressesinflammation and accelerates angiogenesis during wound healing.Hydrogels not only have adequate mechanical properties and self-healingability but can also support tissue adhesion. They can also promote the secretionof inducible cAMP early repressor, which promotes the polarization ofmacrophages toward the M2 type. The in vivo results confirm that hydrogelpromotes diabetic wound repair and skin regeneration by exerting rapid antiinflammatoryeffects and promoting angiogenesis. Therefore, this hydrogelsystem represents an effective strategy for treating diabetic wounds.

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