Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis

Yokoyama Shota; Onozawa Masahiro; Yoshida ShotaMiyashita NaokiKimura HiroyukiTakahashi ShogoMatsukawa ToshihiroGoto HidekiFujisawa ShinichiMiki KosukeHidaka DaisukeHashiguchi JunichiWakasa KentaroIbata MakotoTakeda YukariShigematsu AkioFujimoto KatsuyaTsutsumi YutakaMori AkioIshihara ToshimichiKakinoki YasutakaKondo TakeshiHashimoto DaigoTeshima Takanori

首页> 外文期刊>British Journal of Haematology >Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis

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Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis

机译：Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis

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Recent advances in next-generation sequencing (NGS) have enabled the detection of subclinical minute FLT3-ITD. We selected 74 newly diagnosed, cytogenetically normal acute myeloid leukaemia (AML) samples in which FLT3-ITD was not detected by gel electrophoresis. We sequenced them using NGS and found minute FLT3-ITDs in 19 cases. We compared cases with clinically relevant FLT3-ITD (n = 37), cases with minute FLT3-ITD (n = 19) and cases without detectable FLT3-ITD (n = 55). Molecular characteristics (location and length) of minute FLT3-ITD were similar to those of clinically relevant FLT3-ITD. Survival of cases with minute FLT3-ITD was similar to that of cases without detectable FLT3-ITD, whereas the relapse rate within 1 year after onset was significantly higher in cases with minute FLT3-ITD. We followed 18 relapsed samples of cases with clinically FLT3-ITD-negative at diagnosis. Two of 3 cases with minute FLT3-ITD relapsed with progression to clinically relevant FLT3-ITD. Two of 15 cases in which FLT3-ITD was not detected by NGS relapsed with the emergence of minute FLT3-ITD, and one of them showed progression to clinically relevant FLT3-ITD at the second relapse. We revealed the clonal dynamics of subclinical minute FLT3-ITD in clinically FLT3-ITD-negative AML. Minute FLT3-ITD at the initial AML can expand to become a dominant clone at relapse.

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《British Journal of Haematology》 |2023年第6期|1144-1152|共9页
作者
Yokoyama Shota; Onozawa Masahiro; Yoshida ShotaMiyashita NaokiKimura HiroyukiTakahashi ShogoMatsukawa ToshihiroGoto HidekiFujisawa ShinichiMiki KosukeHidaka DaisukeHashiguchi JunichiWakasa KentaroIbata MakotoTakeda YukariShigematsu AkioFujimoto KatsuyaTsutsumi YutakaMori AkioIshihara ToshimichiKakinoki YasutakaKondo TakeshiHashimoto DaigoTeshima Takanori;
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作者单位

Hokkaido University,Hokkaido Univ;

Div Lab & Transfus Med,Hokkaido Univ Hosp;

Dept Hematol,Teine Keijinkai HospDept Hematol,Sapporo Hokuyu HospDept Hematol,Kitami Red Cross HospDiv Hematol,Obihiro Kosei Gen HospDept Hematol,Sapporo Kosei Gen HospDept Hematol,Tonan HospDept Hematol,Kushiro Rosai HospDept Hematol,Natl Hosp Org Hokkaido Canc CtrDept Hematol,Hakodate Municipal HospDept Hematol,Kin Ikyo Chuo HospDept Hematol,Asahikawa City HospBlood Disorders Ctr,Aiiku Hosp;

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正文语种英语
中图分类血液及淋巴系疾病;
关键词
acute myeloid leukaemia (AML); clonal diversity; Hokkaido Leukemia Net (HLN); minute FLT3-ITD; next-generation sequencing (NGS); relapse; INTERNAL TANDEM DUPLICATION; MUTATIONS; AML; RELAPSE; GENE; HETEROGENEITY; EVOLUTION; SAMPLES; LENGTH; ADULTS;

Subclinical minute FLT3-ITD clone can be detected in clinically FLT3-ITD-negative acute myeloid leukaemia at diagnosis

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