Giardia Lamblia Subtypes and Their Relationship with Clinical Symptoms in Patients with Giardiasis

Soghra Viesy; Jahangir Abdi; Karimeh HaghaniReza ValizadehA. Mirzaei

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Giardia Lamblia Subtypes and Their Relationship with Clinical Symptoms in Patients with Giardiasis

机译：Giardia Lamblia Subtypes and Their Relationship with Clinical Symptoms in Patients with Giardiasis

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Giardia lamblia has proved to be the most common intestinal protozoan parasite in humansthat causes giardiasis. Given the high mutations in the genome of this parasite, the presentstudy was conducted to determine the prevalence of Giardia lamblia subtypes and their relationshipwith clinical symptoms in patients who appear to have giardiasis. In 69 stool specimens withan appropriate number of giardia cysts, the DNA was first purified, and the genotype was thendetermined based on the glutamate dehydrogenase (gdh) gene sequence using PCR-RFLP. Datawere collected on the clinical symptoms of the patients through a questionnaire, and theirrelationship with molecular results was studied. Four samples (5.8%) were found to be of subtypeAI, 51 (73.9%) of subtype AII and 14 (20.3 %) of subtype BIII. No BIV subtype was found in thepresent study. A correlation was observed between Giardia lamblia genotypes (AI, AII and BIII)and abdominal pain. All of the people (100%) who had the AI genotype (i.e. the zoonosis subtype)had been losing weight. There was a significant correlation between weight loss and the AI subtype.All of the people (100%) infected with the BIII genotype experienced diarrhea, and thisgenotype was found to be associated with diarrhea. The present study found abdominal pain to bethe most common symptom of giardiasis in Ilam province. Moreover, humans were found to bethe main reservoir for giardia lamblia, although zoonosis subtypes such as AI and BIII still exist inthe region and pose a risk for a giardiasis epidemic.

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《Infectious disorders drug targets》 |2020年第3期|396-400|共5页
作者
Soghra Viesy; Jahangir Abdi; Karimeh HaghaniReza ValizadehA. Mirzaei;
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作者单位

Student Research Committee, Ilam University of Medical Sciences, Ilam;

Department of Parasitology, School of Medicine, Ilam University of Medical Sciences, Ilam;

Department of Biochemistry, Faculty of Medicine, Ilam University of Medical Sciences, IlamDepartment of Psychiatry, Faculty of Medicine, Ilam University of Medical Sciences, Ilam;

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正文语种英语
中图分类药学;
关键词
Subtypes; giardia lamblia; clinical symptoms; Giardiasis; giardia cysts; coproscopy;

Giardia Lamblia Subtypes and Their Relationship with Clinical Symptoms in Patients with Giardiasis

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