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Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish

机译：Long noncoding RNAs implicated in embryonic development in Ybx1 knockout zebrafish

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摘要

Y‐box‐binding protein 1 (Ybx1, YB‐1), also known as Y‐box transcription factor, is involved in a variety of biological processes (BPs) and pathways, including embryogenesis, reproduction and development in vertebrates. Several noncoding RNAs regulate Ybx1 signaling. However, the role of long noncoding RNAs (lncRNAs) in embryogenesis remains incompletely understood. Here, we investigated the possible involvement of lncRNAs in Ybx1 ‐mediated regulation of vertebrate development by performing systematic transcriptome analysis of RNA sequencing data derived from ybx1 homozygous mutant zebrafish on day 5 (day5_ ybx1sup−/−/sup ) and wild‐type zebrafish on days 5 and 6 (day5_ ybx1sup+/+/sup and day6_ ybx1sup+/+/sup ). We identified several lncRNAs affected by ybx1 disruption that may target reduction–oxidation‐related genes, such as duox (NADPH oxidase) and noxo1a (NADPH oxidase organizer). Knockdown of three selected lncRNAs led to morphological deformation of larvae, implying an involvement of these lncRNAs in zebrafish embryo development. In summary, our study provides new insights into the lncRNA‐mediated mechanisms underlying development in Ybx1 ‐deficient zebrafish larvae.

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