• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biology bulletin >Promising Approaches to Assessing Public Health Risk with Real Ways of Introducing a Toxicant into the Body
【24h】

Promising Approaches to Assessing Public Health Risk with Real Ways of Introducing a Toxicant into the Body

机译：Promising Approaches to Assessing Public Health Risk with Real Ways of Introducing a Toxicant into the Body

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Abstract—Promising areas of scientific and technological development of the Russian Federation in the field of ecology and nature management and related problems and solutions for assessing the public health risk are considered. The prospects of creating methods for rapid assessment of public health risks using modern data and representations of toxicokinetics and toxicodynamics of a substance are substantiated. It is shown that it is possible to deduce adequate mathematical dependences for substances regardless of their structure, based on modern concepts of the formation of the dose of a toxicant in the body from the position of toxicokinetics. To make an adequate forecast of toxicometric indicators (LD, ED) when constructing mathematical models, it is proposed to use pharmaco- and toxicokinetic parameters estimated within the normal range as independent variables (for medicinal substances not higher than their therapeutic doses, and for other substances not higher than their thresholds). Our definitions of the notions of a norm, the threshold of harmful action, and pre-pathological conditions of the body from the position of detoxification of substances are presented. The reference range of the norm for the values of the pharmaco- and toxicokinetic parameters of a substance is justified taking into account individual differences of the organism within the boundary of the standard deviation (±2δ) from the normatively established value, which does not lead to any negative (side) physiological deviations.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号