Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

Xiangjing Meng; Yanhua Wang; Ting Wang

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Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

机译：Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

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Compared with the T-cell potential of particulate matter (PM) in animal studies, comprehensive evaluation on the impairments of T-cell response and exposure—response from PM and its components in human population is limited. There were 768 participants in this study. We measured environmental PM and its polycyclic aromatic hydrocarbons (PAHs) and metals and urinary metabolite levels of PAHs and metals among population. T lymphocyte and its subpopulation (CD4+ T cells and CD8+ T cells) and the expressions of T-bet, GATA3, RORyt, and FoxP3 were measured. We explored the exposure-response of PM compositions by principal component analysis and mode of action by mediation analysis. There was a significant decreasing trend for T lymphocytes and the levels of T-bet and GATA3 with increased PM levels. Generally, there was a negative correlation between PM, urinary 1-hydroxypyrene, urinary metals, and the levels of T-bet and GAT A3 expression. Additionally, CD4+ T lymphocytes were found to mediate the associations of PM25 with T-bet expression. PM and its bound PAHs and metals could induce immune impairments by altering the T lymphocytes and genes of T-bet and GATA3.

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《Environmental Science & Technology: ES&T》 |2023年第1期|375-384|共10页
作者
Xiangjing Meng; Yanhua Wang; Ting Wang;
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作者单位

Shandong First Medical University & Shandong Academy of Medical Sciences, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong 250062, China;

National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 1000S0, China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
中图分类环境科学、安全科学;
关键词
particulate matter; polycyclic aromatic hydrocarbons; metals; T lymphocyte;

Particulate Matter and Its Components Induce Alteration on the T-Cell Response: A Population Biomarker Study

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