Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

Hichem Moulahoum; Faezeh Ghorbanizamani; Zineb KhiariMohamed ToumiYasmina BenazzougSuna TimurFigen Zihnioglu

首页> 外文期刊>Phytochemical Analysis >Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

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Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

机译：Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

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Abstract Introduction The chronicity of advanced glycation end‐products (AGEs) imparts various damages resulting in metabolic dysfunction and diseases involving inflammation and oxidative stress. The use of plant extracts is of high interest in complementary medicine. Yet, extracts are multicomponent mixtures, and difficult to pinpoint their exact mechanism. Objectives We hypothesise that network pharmacology and bioinformatics can help experimental findings depict the exact active components and mechanism of action by which they induce their effects. Additionally, the toxicity and variability can be lowered and standardised with proper encapsulation methods. Methodology Here, we propose the formulation of phytoniosomes encapsulating two Artemisia species (Artemisia dracunculus and Artemisia absinthium) to mitigate AGEs and their induced cell redox dysregulation in the liver. Extracts from different solvents were identified via liquid chromatography quadrupole time‐of‐flight mass spectrometry (LC‐Q‐TOF‐MS/MS). Phytoniosomes were explored for their anti‐glycating effect and modulation of AGE‐induced damages in THLE‐2 liver cells. Network pharmacology tools were used to identify possible targets and signalling pathways implicated. Results Data demonstrated that A. absinthium phytoniosomes had a significant anti‐AGE effect comparable to reference molecules and higher than A. dracunculus. They were able to restore cell dysfunction through the restoration of tumour necrosis alpha (TNF‐α), interleukin 6 (IL‐6), nitric oxide, and total antioxidant capacity. Phytoniosomes were able to protect cells from apoptosis by decreasing caspase 3 activity. Network pharmacology and bioinformatic analysis confirmed the induction of the effect via Akt‐PI3K‐MAPK and AGE‐RAGE signalling pathways through quercetin and luteolin actions. Conclusion The current report highlights the potential of Artemisia phytoniosomes as strong contenders in AGE‐related disease therapy.

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《Phytochemical Analysis》 |2022年第7期|1058-1067|共10页
作者
Hichem Moulahoum; Faezeh Ghorbanizamani; Zineb KhiariMohamed ToumiYasmina BenazzougSuna TimurFigen Zihnioglu;
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作者单位

Ege University;

Higher Normal School Kouba;

University of Algiers 1USTHB;

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原文格式 PDF
正文语种英语
中图分类植物学;
关键词
AGE‐RAGE pathway; age‐related diseases; Artemisia; network pharmacology; phytoniosome;

Combination of LC‐Q‐TOF‐MS/MS, network pharmacology, and nanoemulsion approaches identifies active compounds of two Artemisia species responsible for tackling early diabetes‐related metabolic complications in the liver

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