Serum Globulin Is Associated with Endoscopic Findings and Mucosal Healing in Japanese Patients with Ulcerative Colitis

Shiraishi Kana; Furukawa Shinya; Yagi SenMori KenichirouNinomiya TomoyukiKawasaki KeitarouMizukami YujiSuzuki SeiyuuUraoka MasayoshiShibata NaozumiNakamura SanaeImamine SatoshiMurakami HidehiroOhashi KatsuhisaTorisu MasamotoYano MakotoHasebe AkiYano HarumiMurakami MasatoTakeshita EijiIkeda YoshioHiasa Yoichi

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Serum Globulin Is Associated with Endoscopic Findings and Mucosal Healing in Japanese Patients with Ulcerative Colitis

机译：Serum Globulin Is Associated with Endoscopic Findings and Mucosal Healing in Japanese Patients with Ulcerative Colitis

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Background Serum globulin is an inflammation marker. To date, no evidence regarding the association between serum globulin and disease activity in patients with ulcerative colitis has been reported. Aims We evaluated the association between serum globulin and endoscopic activity in patients with ulcerative colitis. Methods Serum globulin was divided into tertiles based on the distribution of study subjects (low globulin, 3.1 g/dl). A single endoscopic specialist evaluated the endoscopic findings, and mucosal healing was based on Mayo endoscopic subscore. Results A total of 277 patients with ulcerative colitis were included in the study. Serum globulin was independently positively associated with diminished or absent vascular markings [moderate: adjusted odds ratio (OR) 3.70 (95% confidence interval, CI: 1.82-7.88) and high: adjusted OR 2.40 (95%CI: 1.20-4.94), p for trend = 0.005]. A similar positive association between globulin and erosion was found [high: adjusted OR 2.00 (95%CI: 1.05-3.86)]. Serum globulin was independently inversely associated with mucosal healing [moderate: adjusted OR 0.37 (95%CI: 0.18-0.73) and high: adjusted OR 0.31 (95%CI: 0.14-0.64), p for trend = 0.001] and adjusted partial mucosal healing [moderate: OR 0.51 (95%CI: 0.26-0.98), p for trend = 0.048]. The inverse association between globulin and mucosal healing was significant in the low but not the high C-reactive protein group. Conclusions In patients with ulcerative colitis, serum globulin was significantly positively associated with endoscopic activity, and was significantly inversely associated with mucosal healing, especially in the low C-reactive protein group.

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《Digestive Diseases and Sciences》 |2022年第1期|233-240|共8页
作者
Shiraishi Kana; Furukawa Shinya; Yagi SenMori KenichirouNinomiya TomoyukiKawasaki KeitarouMizukami YujiSuzuki SeiyuuUraoka MasayoshiShibata NaozumiNakamura SanaeImamine SatoshiMurakami HidehiroOhashi KatsuhisaTorisu MasamotoYano MakotoHasebe AkiYano HarumiMurakami MasatoTakeshita EijiIkeda YoshioHiasa Yoichi;
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作者单位

Dept Gastroenterol,Sumitomo Besshi Hosp;

Uraoka Gastrointestinal Clin;

Dept Gastroenterol,Ehime Prefectural Niihama HospDept Gastroenterol,Shinsenkai Matsuyama Madonna HospDept Internal Med,Shiritsu Oozu HospDept Internal Med,Saiseikai Matsuyama HospOhashi Clin Participate Gastroenterol & AnoproctoDept Internal Med,Saiseikai Saijo HospYano ClinDept Gastroenterol,Shikoku Canc CtrDept Gastroenterol,Saijo City Shuso HospDept Gastroenterol,Murakamikinen HospGrad Sch Med,Ehime UnivEndoscopy Ctr,Ehime Univ HospHlth Serv Ctr,Ehime UnivDept Gastroenterol,Ehime Prefectural Cent HospDept Internal Med,Saiseikai Imabari HospDept Gastroenterol,Matsuyama Shimin Hosp;

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正文语种英语
中图分类消化系及腹部疾病;
关键词
Globulins; Ulcerative colitis; Endoscopy; Biomarkers;

Serum Globulin Is Associated with Endoscopic Findings and Mucosal Healing in Japanese Patients with Ulcerative Colitis

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