...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Autism research : >Abnormal gray matter volume and functional connectivity patterns in social cognition‐related brain regions of young children with autism spectrum disorder
【24h】

Abnormal gray matter volume and functional connectivity patterns in social cognition‐related brain regions of young children with autism spectrum disorder

机译：Abnormal gray matter volume and functional connectivity patterns in social cognition‐related brain regions of young children with autism spectrum disorder

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

Abstract Autism spectrum disorder (ASD) is associated with abnormal brain imaging findings, but descriptions thereof are inconsistent. The aim of the present study was to investigate brain abnormalities in young children with ASD using a combination of structural and functional brain magnetic resonance imaging (MRI). Structural and resting‐state functional MRI was performed in 67 children with ASD (aged 2–7?years) and 39 age‐matched typically developing (TD) controls. Voxel‐based morphometry was used to evaluate differences in brain structure between groups. Topologic parameters of the functional brain network were compared by graph theoretic analysis and network connectomes were compared with network‐based statistics. A support vector machine (SVM) was used to discriminate between ASD and TD groups. Results demonstrated young children with ASD had increased gray matter volumes (GMVs) in the right medial superior frontal gyrus and left fusiform gyrus compared with the TD group. The ASD group had altered subnetwork connectivity in frontal and temporal lobes and other social cognition‐related brain regions. Functional connectivity in the left superior temporal gyrus and left temporal pole of the middle temporal gyrus was positively correlated with adaptability and language developmental quotient (DQ) in children with ASD. The combination of the brain structural and functional features had 86.2% accuracy in discriminating between ASD and TD. The present study shows that young children with ASD have altered GMVs and functional networks in social cognition‐related brain regions, which are potential neuroimaging biomarkers for ASD.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号