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机译:Viewing rare conformations of the beta(2) adrenergic receptor with pressure-resolved DEER spectroscopy
Jules Stein Eye Inst,Univ Calif Los Angeles;
Dept Chem & Syst Biol,Stanford Univ;
Dept Mol & Cellular Physiol,Stanford Univ;
double electron-electron resonance; beta(2) adrenergic receptor; high pressure; conformational selection; basal activity; PROTEIN-COUPLED RECEPTOR; ELECTRON RESONANCE DEER; CONSTITUTIVE ACTIVITY; CRYSTAL-STRUCTURE; LIGAND EFFICACY; ACTIVATION; COMPRESSIBILITY; AGONISTS; BETA(2)-ADRENOCEPTOR; EQUILIBRIA;