• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of polymers and the environment >Drug release kinetics of artemisinin sustained-release particles with two sizes for algal inhibition in different media
【24h】

Drug release kinetics of artemisinin sustained-release particles with two sizes for algal inhibition in different media

机译：Drug release kinetics of artemisinin sustained-release particles with two sizes for algal inhibition in different media

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相关主题

摘要

To avoid the disadvantage that millimeter level artemisinin particles coated with chitosan alginate (CS/AL/AT) are easy to settle and improve the dispersion of granules in water, improved chitosan covered alginate artemisinin particles by ultrasonic technology combined with ion crosslinking method (CS/AL/AT-US) were prepared in this study. The release kinetics of two kinds of particles under different media conditions (temperature, ionic strength, pH, algal liquid, and Taihu Lake water) were studied. The physicochemical characterization showed that the diameter and zeta potential of the CS/AL/AT-US were 1189.5 nm and - 38.0 mV, respectively. Here, the drug release of chitosan-coated artemisinin alginate particles is affected by the temperature, pH, and ionic strength of the release medium. Whether CS/AL/AT or CS/AL/AT-US, drug release increased with the increase of temperature and ionic strength, but decreased with the increase of pH. More importantly, the release kinetics study showed that the release mechanism of the CS/AL/AT-US in Taihu Lake water and algae liquid is matrix dissolution, while the release of CS/AL/AT in Taihu Lake water was controlled by diffusion and skeleton dissolution. The growth experiment of cyanobacteria showed that the CS/AL/AT-US have a long-term inhibitory effect on algae cells, and the inhibitory effect on cyanobacteria increased with the increase of dosing concentration. Our study clearly shows that the particles with reduced diameter have the characteristics of rapid dispersion and continuous release, and have the potential to be applied to the control of cyanobacteria bloom.

著录项

获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号