Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

Oliveira Eduarda R.; Fayer Leonara; Zanette Rafaella S. S.Ladeira Luiz O.de Oliveira Luiz F. C.Maranduba Carlos M. C.Brandao Humberto M.Munk Michele

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Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

机译：Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

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Carboxylated multi-wall carbon nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNT-COOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields.

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《Nanotechnology》 |2022年第6期|共14页
作者
Oliveira Eduarda R.; Fayer Leonara; Zanette Rafaella S. S.Ladeira Luiz O.de Oliveira Luiz F. C.Maranduba Carlos M. C.Brandao Humberto M.Munk Michele;
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作者单位

Univ Fed Juiz de Fora;

Univ Fed Minas Gerais;

Brazilian Agr Res Corp;

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正文语种英语
中图分类特种结构材料;
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carbon materials; in vitro study; nanotechnology; tissue engineering; THERMAL-CONDUCTIVITY; SURFACE; NANOPARTICLES; CYTOTOXICITY; TOXICITY; SCAFFOLD; FUNCTIONALIZATION; DIFFERENTIATION; PROLIFERATION; GENOTOXICITY;

Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth

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