Cardiotoxicity of (?)‐borneol, (+)‐borneol, and isoborneol in zebrafish embryos is associated with Na+/K+‐ATPase and Ca2+‐ATPase inhibition

Xuan Ni; Xiaoyu Yin; Chelimuge QiChunyu LiuHao ChenYini ZhouWuliji AoShuyin BaoJiangdong XueJingfeng YangWu Dong

首页> 外文期刊>Journal of applied toxicology >Cardiotoxicity of (?)‐borneol, (+)‐borneol, and isoborneol in zebrafish embryos is associated with Na+/K+‐ATPase and Ca2+‐ATPase inhibition

【24h】

Cardiotoxicity of (?)‐borneol, (+)‐borneol, and isoborneol in zebrafish embryos is associated with Na+/K+‐ATPase and Ca2+‐ATPase inhibition

机译：Cardiotoxicity of (?)‐borneol, (+)‐borneol, and isoborneol in zebrafish embryos is associated with Na+/K+‐ATPase and Ca2+‐ATPase inhibition

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

Abstract Borneol is an example of traditional Chinese medicine widely used in Asia. There are different isomers of chiral borneol in the market, but its toxicity and effects need further study. In this study, we used zebrafish embryos to examine the effects of exposure to three isomers of borneol [(?)‐borneol, (+)‐borneol, and isoborneol] on heart development and the association with Na+/K+‐ATPase from 4?h post‐fertilization (4?hpf). The results showed that the three isomers of borneol increased mortality and decreased hatching rate when the zebrafish embryo developed to 72?hpf. All three isomers of borneol (0.01–1.0?mM) significantly reduced heart rate from 48 to 120?hpf and reduced the expression of genes related to Ca2+‐ATPase (cacna1ab and cacna1da) and Na+/K+‐ATPase (atp1b2b, atp1a3b, and atp1a2). At the same time, the three isomers of borneol significantly reduced the activities of Ca2+‐ATPase and Na+/K+‐ATPase at 0.1 to 1.0?mM. (+)‐Borneol caused the most significant reduction (p?

著录项

来源
《Journal of applied toxicology》 |2023年第4期|373-386|共14页
作者
Xuan Ni; Xiaoyu Yin; Chelimuge QiChunyu LiuHao ChenYini ZhouWuliji AoShuyin BaoJiangdong XueJingfeng YangWu Dong;
展开▼
作者单位

Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, College of Animal Science and;

Inner Mongolia Research Institute of Traditional Mongolian Medicine Engineering technology/College;

The Medical College of Inner Mongolia Minzu University;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类毒物学（毒理学）;
关键词
borneol; Ca+‐ATPase; heart rate; Na+/K+‐ATPase; zebrafish embryo;

Cardiotoxicity of (?)‐borneol, (+)‐borneol, and isoborneol in zebrafish embryos is associated with Na+/K+‐ATPase and Ca2+‐ATPase inhibition

摘要

著录项

相关主题

期刊订阅