Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands: A test-negative case-control study

Niessen F.A.; Knol M.J.; Hahne S.J.M.Bonten M.J.M.Bruijning-Verhagen P.C.J.L.

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Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands: A test-negative case-control study

机译：Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands: A test-negative case-control study

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© 2022 The AuthorsIntroduction: Real-world vaccine effectiveness (VE) estimates are essential to identify potential groups at higher risk of break-through infections and to guide policy. We assessed the VE of COVID-19 vaccination against COVID-19 hospitalization, while adjusting and stratifying for patient characteristics. Methods: We performed a test-negative case-control study in six Dutch hospitals. The study population consisted of adults eligible for COVID-19 vaccination hospitalized between May 1 and June 28, 2021 with respiratory symptoms. Cases were defined as patients who tested positive for SARS-CoV-2 by PCR during the first 48 h of admission or within 14 days prior to hospital admission. Controls were patients tested negative at admission and did not have a positive test during the 2 weeks prior to hospitalization. VE was calculated using multivariable logistic regression, adjusting for calendar week, sex, age, comorbidity and nursing home residency. Subgroup analysis was performed for age, sex and different comorbidities. Secondary endpoints were ICU-admission and mortality. Results: 379 cases and 255 controls were included of whom 157 (18%) were vaccinated prior to admission. Five cases (1%) and 40 controls (16%) were fully vaccinated (VE: 93%; 95% CI: 81 – 98), and 40 cases (11%) and 70 controls (27%) were partially vaccinated (VE: 70%; 95% CI: 50–82). A strongly protective effect of vaccination was found in all comorbidity subgroups. No ICU-admission or mortality were reported among fully vaccinated cases. Of unvaccinated cases, mortality was 10% and 19% was admitted at the ICU. Conclusion: COVID-19 vaccination provides a strong protective effect against COVID-19 related hospital admission, in patients with and without comorbidity.

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《Vaccine》 |2022年第34期|5044-5049|共6页
作者
Niessen F.A.; Knol M.J.; Hahne S.J.M.Bonten M.J.M.Bruijning-Verhagen P.C.J.L.;
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Julius Center for Health Sciences and Primary Care University Medical Center Utrecht;

Centre for Infectious Disease Control National Institute for Public Health and the Environment;

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正文语种英语
中图分类医学免疫学;
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Vaccine effectiveness against COVID-19 related hospital admission in the Netherlands: A test-negative case-control study

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