Potential neurobiological links between social isolation and Alzheimer's disease risk

Drinkwater Elizabeth; Davies Caitlin; Spires-Jones Tara L.

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Potential neurobiological links between social isolation and Alzheimer's disease risk

机译：Potential neurobiological links between social isolation and Alzheimer's disease risk

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摘要

It is estimated that 40% of dementia cases could be prevented by modification of lifestyle factors that associate with disease risk. One of these potentially modifiable lifestyle factors is social isolation. In this review, we discuss what is known about associations between social isolation and Alzheimer's disease, the most common cause of dementia. This is particularly relevant in the time of the COVID-19 pandemic when social isolation has been enforced with potential emerging negative impacts on cognition. While there are neurobiological mechanisms emerging that may account for the observed epidemiological associations between social isolation and Alzheimer's disease, more fundamental research is needed to fully understand the brain changes induced by isolation that may make people vulnerable to disease.

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《The European journal of neuroscience.》 |2022年第9期|5397-5412|共16页
作者
Drinkwater Elizabeth; Davies Caitlin; Spires-Jones Tara L.;
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University of Edinburgh,Univ Edinburgh;

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正文语种英语
中图分类神经病学与精神病学;
关键词
Alzheimer's disease; COVID-19; social isolation; synapse; MILD COGNITIVE IMPAIRMENT; ISOLATION-TRIGGERED ONSET; DEPRESSIVE-LIKE BEHAVIOR; NEUROTROPHIC FACTOR; NEUROINFLAMMATORY RESPONSE; INCIDENT DEMENTIA; MEMORY DEFICIT; ANIMAL-MODEL; LIFE-STYLE; BDNF;

Potential neurobiological links between social isolation and Alzheimer's disease risk

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