The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device‐based treatment of sudden cardiac arrest

Amy E. Thompson; Brett Atwater; Lucas BoersmaIan CrozierGregory EngelPaul FriedmanJ. Rod GimbelBradley P. KnightJaimie ManlucuFrancis MurgatroydDavid ODonnellJuergen KuschykPaul DeGroot

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The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device‐based treatment of sudden cardiac arrest

机译：The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device‐based treatment of sudden cardiac arrest

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Abstract Introduction The extravascular implantable cardioverter‐defibrillato (EV ICD) system with substernal lead placement is a novel nontransvenous alternative to current commercially available ICD systems. The EV ICD provides defibrillation and pacing therapies without the potential long‐term complications of endovascular lead placement but requires a new procedure for implantation with a safety profile under evaluation. Methods This paper summarizes the development of the EV ICD, including the preclinical and clinical evaluations that have contributed to the system and procedural refinements to date. Results Extensive preclinical research evaluations and four human clinical studies with >140 combined acute and chronic implants have enabled the development and refinement of the EV ICD system, currently in worldwide pivotal study. Conclusion The EV ICD may represent a clinically valuable solution in protecting patients from sudden cardiac death while avoiding the long‐term consequences of transvenous hardware. The EV ICD offers advantages over transvenous and subcutaneous systems by avoiding placement in the heart and vasculature; relative to subcutaneous systems, EV ICD requires less energy for defibrillation, enabling a smaller device, and provides pacing features such as antitachycardia and asystole pacing in a single system.

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《Journal of cardiovascular electrophysiology》 |2022年第6期|1085-1095|共11页
作者
Amy E. Thompson; Brett Atwater; Lucas BoersmaIan CrozierGregory EngelPaul FriedmanJ. Rod GimbelBradley P. KnightJaimie ManlucuFrancis MurgatroydDavid ODonnellJuergen KuschykPaul DeGroot;
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作者单位

Cardiology/Electrophysiology,Inova Medical Group;

Cardiology/Electrophysiology,St. Antonius Hospital Nieuwegein and Amsterdam UMC;

Cardiology/Electrophysiology,Christchurch HospitalCardiology/Electrophysiology,Palo Alto Medical FoundationCardiology/Electrophysiology,Mayo ClinicCardiology/Electrophysiology,Lutheran Medical GroupCardiology/Electrophysiology,Northwestern UniversityCardiology/Electrophysiology,London Health Sciences CentreCardiology/Electrophysiology,King's College HospitalMedtronic Clinical Research,Medtronic plcCardiology/Electrophysiology,GenesisCareCardiology/Electrophysiology,University of MannheimResearch & Technology,Medtronic plc, Mounds View;

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正文语种英语
中图分类人体生理学;
关键词
anterior mediastinum; arrhythmia; extravascular; ICD; substernal;

The development of the extravascular defibrillator with substernal lead placement: A new Frontier for device‐based treatment of sudden cardiac arrest

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