~1H‐Nuclear Magnetic Resonance Metabolomics Analysis of Arabidopsis thaliana Exposed to Perfluorooctanoic Acid and Perfluoroctanesulfonic Acid

Liam OHara; James G. Longstaffe

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~1H‐Nuclear Magnetic Resonance Metabolomics Analysis of Arabidopsis thaliana Exposed to Perfluorooctanoic Acid and Perfluoroctanesulfonic Acid

机译：~1H‐Nuclear Magnetic Resonance Metabolomics Analysis of Arabidopsis thaliana Exposed to Perfluorooctanoic Acid and Perfluoroctanesulfonic Acid

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Perfluorinated alkyl substances (PFAS) are ubiquitous environmental contaminants that are widely used inconsumer products and fire suppression foams. The presence of PFAS in ground and surface water can create a route forPFAS to enter the soil, exposing ecosystems (including agroecosystems), where they will move through the food web viabiomagnification. The toxicity of PFAS to plants, particularly in agricultural ecosystems, is of emerging concern due to theapplication of biosolids that are often contaminated with PFAS. Nevertheless, due to the low concentrations of PFAS in mostagricultural soils, the direct impact of PFAS on plant health is not well understood. We used 1H‐nuclear magnetic resonance(NMR) metabolomics to explore the effects of exposure of two key PFAS, perfluorooctanoic acid and perfluorooctanesulfonicacid, on Arabidopsis thaliana, a model organism. We found that Arabidopsis exhibited an accumulation of multiplemetabolites, including soluble sugars (glucose and sucrose), multiple amino acids, and tri‐carboxylic acid (TCA) cycleintermediates, suggesting that PFAS exposure impacts the metabolism of plants by causing an accumulation of stress‐relatedamino acids and soluble sugars that drives increased activity of the TCA cycle. The present study shows that 1H‐NMRmetabolomics is a viable tool for investigating changes in the metabolic profile of plants exposed to PFAS and can be usedto illuminate the stress response of plants in a high‐throughput, nonbiased manner.

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《Environmental toxicology and chemistry /》 |2023年第3期|663-672|共10页
作者
Liam OHara; James G. Longstaffe;
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作者单位

School of Environmental Sciences, University of Guelph, Guelph, Ontario, Canada;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
原文格式 PDF
正文语种英语
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Metabolism; metabolomics; nuclear magnetic resonance; perfluoroalkyl substance; plant; stress;

~1H‐Nuclear Magnetic Resonance Metabolomics Analysis of Arabidopsis thaliana Exposed to Perfluorooctanoic Acid and Perfluoroctanesulfonic Acid

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