The relationship between excessive dietary fructose consumption and paediatric fatty liver disease

Johanna K. DiStefano; Gabriel Q. Shaibi

首页> 外文期刊>Pediatric obesity. >The relationship between excessive dietary fructose consumption and paediatric fatty liver disease

【24h】

The relationship between excessive dietary fructose consumption and paediatric fatty liver disease

机译：The relationship between excessive dietary fructose consumption and paediatric fatty liver disease

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相关主题

摘要

The global prevalence of non-alcoholic fatty liver disease (NAFLD) in children and adolescents is escalating and currently represents the most common chronic liver disease in the paediatric population. NAFLD is associated with high daily caloric intake and sedentary behaviour, with excessive consumption of added sugar emerging as an important contributor to NAFLD risk in children. This is a particularly important factor for adolescents with obesity, who are the heaviest consumers of added sugar. Table sugar, or sucrose, is a disaccharide comprised of fructose and glucose, yet only fructose has been strongly linked to NAFLD pathogenesis largely due to the unique characteristics of its metabolism and detrimental effects on key metabolic pathways. To date, the relationship between excessive fructose intake and risk of NAFLD in children and adolescents remains incompletely understood, and it is not yet known whether fructose actually causes NAFLD or instead exacerbates hepatic fat accumulation and possible hepatocellular injury only within the context of cardiometabolic factors. The purpose of this review is to summarize recent studies linking fructose consumption with NAFLD in the paediatric population and integrate results from interventional studies of fructose restriction in children and adolescents on NAFLD and related metabolic markers. Given the overall positive impact of lifestyle modifications in the management of paediatric NAFLD, reduction of added sugar consumption may represent an important, early opportunity to mitigate or prevent NAFLD in high-risk children and adolescents.

著录项

来源
《Pediatric obesity.》 |2021年第6期|e12759-e12759|共1页
作者
Johanna K. DiStefano; Gabriel Q. Shaibi;
展开▼
作者单位

Diabetes and Fibrotic Disease Research Unit, Translational Genomics Research Institute, Phoenix;

展开▼
收录信息
原文格式 PDF
正文语种英语
中图分类儿科学;
关键词
fructose; hepatic steatosis; liver fibrosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; uric acid;

The relationship between excessive dietary fructose consumption and paediatric fatty liver disease

摘要

著录项

相关主题

期刊订阅