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Pharmacokinetic analysis of different contrast agents on multiphase enhanced MRI for microvascular invasion: preoperative prediction in hepatocellular carcinoma

机译:Pharmacokinetic analysis of different contrast agents on multiphase enhanced MRI for microvascular invasion: preoperative prediction in hepatocellular carcinoma

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Background The preoperative diagnosis of microvascular invasion (MVI) for the solitary small hepatocellular carcinoma (sHCC) is crucial for the decision of surgical strategies. Purpose To compare the kinetic parameters and diagnostic effects of two contrast agents for preoperatively predicting MVI of sHCC on multiphase enhanced magnetic resonance imaging (MRI). Material and Methods Two groups of patients with known solitary sHCC underwent an enhanced MRI examination before hepatic resection: Data A (n?=?61) patients underwent Gd-EOB-DTPA-enhanced MRI, and Data B (n?=?41) patients had a normal contrast agent. The two sets of data were processed in the same way. Arterial peritumoral enhancement measured from multiphase enhanced MRI was analyzed using quantitative kinetic parameters, including initial signal enhancement (SE_(1)), peak signal enhancement (SE_(peak)), and calculation of the signal enhancement ratio (SE_(R)). Results The statistical analysis showed that the average SE_(1)and SE_(R)(Data A) for the MVI-positive group were significantly higher ( P ?

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