Two-step recognition of HIV-1 DNA in the cytosol

Dopkins N.; Nixon D.F.

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Two-step recognition of HIV-1 DNA in the cytosol

机译：Two-step recognition of HIV-1 DNA in the cytosol

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© 2022 Elsevier LtdRetroviral DNA induces the production of interferons. A new study by Yoh et al. showed that the host factor ‘PQBP1’ primes immune-recognition of retroviral DNA by recruiting the cytosolic DNA scavenger ‘cGAS’ to the HIV-1 capsid. Their findings support the importance of innate immune sensing in HIV-1 infection.

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来源
《Trends in Microbiology》 |2023年第5期|430-431|共2页
作者
Dopkins N.; Nixon D.F.;
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作者单位

Division of Infectious Diseases Department of Medicine Weill Cornell Medicine;

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原文格式 PDF
正文语种英语
中图分类微生物学;
关键词
capsid protein; cGAS; HIV-1 infection; human endogenous retroviruses; retroviral life cycle;

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Two-step recognition of HIV-1 DNA in the cytosol

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