RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

Qu Jianwei; Yan Haimeng; Hou YifanCao WenLiu YangZhang EnfanHe JingsongCai Zhen

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RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

机译：RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

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RNA demethylase ALKBH5 takes part in the modulation of N-6-methyladenosine (m(6)A) modification and controls various cell processes. ALKBH5-mediated m(6)A demethylation regulates gene expression by affecting multiple events in RNA metabolism, e.g., pre-mRNA processing, mRNA decay and translation. Mounting evidence shows that ALKBH5 plays critical roles in a variety of human malignancies, mostly via post-transcriptional regulation of oncogenes or tumor suppressors in an m(6)A-dependent manner. Meanwhile, increasing non-coding RNAs are recognized as functional targets of ALKBH5 in cancers. Here we reviewed up-to-date findings about the pathological roles of ALKBH5 in cancer, the molecular mechanisms by which it exerts its functions, as well as the underlying mechanism of its dysregulation. We also discussed the therapeutic implications of targeting ALKBH5 in cancer and potential ALKBH5-targeting strategies.

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《Journal of Hematology and Oncology》 |2022年第1期|共24页
作者
Qu Jianwei; Yan Haimeng; Hou YifanCao WenLiu YangZhang EnfanHe JingsongCai Zhen;
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Zhejiang Univ;

Zhejiang Univ;

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正文语种英语
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m(6)A modification; ALKBH5; RNA demethylation; Cancer; Gene regulation; Therapeutic target; SINGLE-NUCLEOTIDE-RESOLUTION; MESSENGER-RNA; NUCLEAR-RNA; OXIDATIVE DEMETHYLATION; DNA-DAMAGE; STEM-CELLS; N-6-METHYLADENOSINE RNA; PROMOTES PROLIFERATION; LUNG ADENOCARCINOMA; CRYSTAL-STRUCTURES;

RNA demethylase ALKBH5 in cancer: from mechanisms to therapeutic potential

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