Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: Binding and aggregation studies

Li Mao; Matkovic Marija; Piantanida IvoSchmuck Carsten

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Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: Binding and aggregation studies

机译：Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: Binding and aggregation studies

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An arginine mimetic, featuring a guanidiniocarbonypyrrol as artificial anion binding site (GCP), was introduced into short peptides to study their binding and aggregation with double stranded DNA and RNA. While the incorporation of this GCP modification did not significantly change the overall binding affinity for DNA/RNA, their interactions were more sensitive with respect to the type of polynucleotides. Peptide 4, with four GCP modifications, exhibited amazing fluorescent selectivity for AU-and (to a lesser extent) AT-sequences. GC-containing DNA showed much lower response. Additionally, exclusively tri-GCP modified peptide 3 showed intriguing exciton-coupled bisignate ICD bands for all studied DNA/RNA which suggested that a well-defined GCP-dimer bound into DNA/RNA groove. (C) 2017 Elsevier Ltd. All rights reserved.

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《Bioorganic and medicinal chemistry》 |2017年第6期|1875-1880|共6页
作者
Li Mao; Matkovic Marija; Piantanida IvoSchmuck Carsten;
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作者单位

Univ Duisburg Essen, Inst Organ Chem, D-45117 Essen, Germany;

Rudjer Boskovic Inst, Div Organ Chem & Biochem, POB 180, Zagreb 10002, Croatia;

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原文格式 PDF
正文语种英语
中图分类药学;
关键词
Arginine mimic; Polynucleotide binding; DNA/RNA recognition; Hydrogen bonds; Ion pair;

Incorporation of arginine mimetic residue into peptides for recognition of double stranded nucleic acid structure: Binding and aggregation studies

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