The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis

Tautvydas Paskevicius; Joanna Jung; Myriam PujolPaul EggletonWenying QinAlison RobinsonNick GutowskiJanet HolleyMiranda SmallwoodJia NewcombeDouglas ZochodneXing‐Zhen ChenJingfeng TangAllison KrausMarek MichalakLuis B. Agellon

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The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis

机译：The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis

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Abstract We previously showed that calnexin (Canx)‐deficient mice are desensitized to experimental autoimmune encephalomyelitis (EAE) induction, a model that is frequently used to study inflammatory demyelinating diseases, due to increased resistance of the blood‐brain barrier to immune cell transmigration. We also discovered that Fabp5, an abundant cytoplasmic lipid‐binding protein found in brain endothelial cells, makes protein‐protein contact with the cytoplasmic C‐tail domain of Canx. Remarkably, both Canx‐deficient and Fabp5‐deficient mice commonly manifest resistance to EAE induction. Here, we evaluated the importance of Fabp5/Canx interactions on EAE pathogenesis and on the patency of a model blood‐brain barrier to T‐cell transcellular migration. The results demonstrate that formation of a complex comprised of Fabp5 and the C‐tail domain of Canx dictates the permeability of the model blood‐brain barrier to immune cells and is also a prerequisite for EAE pathogenesis.

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《The FASEB Journal》 |2020年第12期|16662-16675|共14页
作者
Tautvydas Paskevicius; Joanna Jung; Myriam PujolPaul EggletonWenying QinAlison RobinsonNick GutowskiJanet HolleyMiranda SmallwoodJia NewcombeDouglas ZochodneXing‐Zhen ChenJingfeng TangAllison KrausMarek MichalakLuis B. Agellon;
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作者单位

Department of Biochemistry,University of Alberta;

Department of Biomedical and Clinical Sciences,University of Exeter Medical School;

National “111” Center for Cellular Regulation and Molecular Pharmaceutics,Hubei University ofNeuroResource, Department of Neuroinflammation,University College LondonDepartment of Medicine (Neurology),University of AlbertaDepartment of Pathology,Case Western Reserve UniversitySchool of Human Nutrition,McGill University;

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正文语种英语
中图分类生物化学;
关键词
blood brain barrier; calnexin; chaperone; fatty acid binding protein; multiple sclerosis;

The Fabp5/calnexin complex is a prerequisite for sensitization of mice to experimental autoimmune encephalomyelitis

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