The anabolic applications of androgens in older adults with functional limitations

Arijeet K.Gattu; Anna L.Goldman; Ezgi CaliskanGuzelceFrancescaGalbiatiShalenderBhasin

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The anabolic applications of androgens in older adults with functional limitations

机译：The anabolic applications of androgens in older adults with functional limitations

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Abstract Aging is associated with a progressive decrease in skeletal muscle mass, strength and power and impairment of physical function. Serum testosterone concentrations in men decrease with advancing age due to defects at all levels of the hypothalamic-pituitary–testicular axis. Testosterone administration increases skeletal muscle mass, strength and power in older men with low or low normal testosterone levels, but the effects on performance-based measures of physical function have been inconsistent. Adequately powered randomized trials are needed to determine the long-term safety and efficacy of testosterone in improving physical function and quality of life in older adults with functional limitations.

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来源
《Reviews in endocrine & metabolic disorders》 |2022年第6期|1209-1220|共12页
作者
Arijeet K.Gattu; Anna L.Goldman; Ezgi CaliskanGuzelceFrancescaGalbiatiShalenderBhasin;
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作者单位

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women’s Hospital,Harvard Medical;

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原文格式 PDF
正文语种英语
中图分类内分泌腺疾病及代谢病;
关键词
Androgens; Testosterone and skeletal muscle; Sarcopenia; Anabolic effect of androgens;

The anabolic applications of androgens in older adults with functional limitations

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