Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats

Ming Chu; Guofeng Fu; Jingjing DengRuoxi WangQiming FanZuxin ChenJin LuXin‐an Liu

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Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats

机译：Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats

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Abstract Arecoline is a pharmacologically active alkaloid isolated from Areca catechu. There are no published data available regarding the inhalation toxicity of arecoline in animals. This study aimed to evaluate the inhalation toxicity of arecoline in vitro and in vivo. For this purpose, arecoline benzoate (ABA) salt was prepared to stabilize arecoline in an aerosol. The MTT assay determined the half‐maximal inhibitory concentration values of ABA and arecoline in A549 cell proliferation to be 832 and 412?μg/ml, respectively. The toxicity of acute and subacute inhalation in Sprague–Dawley rats was evaluated using the guidelines of the Organization for Economic Cooperation and Development. For acute inhalation, the median lethal concentration value of ABA solvent was >5175?mg/m3. After the exposure and during the recovery period, no treatment‐related clinical signs were observed. In the 28‐Day inhalation toxicity test, daily nose‐only exposure to 2510?mg/m3 aerosol of the ABA solvent contained 75?mg/m3 ABA for male rats and 375?mg/m3 ABA for female rats, which caused no observed adverse effects, except for the decreased body weight gain in male rats exposed to 375?mg/m3 ABA. In this study, the no observed adverse effect level (NOAEL) for the 28‐day repeated dose inhalation of ABA aerosol was calculated to be around 13?mg/kg/day for male rats and 68.8?mg/kg/day for female rats, respectively.

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来源
《Journal of applied toxicology》 |2022年第8期|1396-1410|共15页
作者
Ming Chu; Guofeng Fu; Jingjing DengRuoxi WangQiming FanZuxin ChenJin LuXin‐an Liu;
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作者单位

Laboratory of Life and Health Sciences,Shenzhen First Union Technology Co., Ltd.;

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain;

Guangdong Zhongke EnHealth Science and Technology Co., Ltd.Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory,Brain;

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原文格式 PDF
正文语种英语
中图分类毒物学（毒理学）;
关键词
28‐day inhalation toxicity; acute inhalation toxicity; aerosol; Arecoline benzoate; cytotoxicity; NOAEL;

Evaluation of the inhalation toxicity of arecoline benzoate aerosol in rats

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