Bioaccessibility of arsenic from contaminated soils and alteration of the gut microbiome in an in vitro gastrointestinal model

Griggs J.L.; Chi L.; Lu K.Fry R.C.Hanley N.M.Kohan M.Herbin-Davis K.Thomas D.J.Bradham K.D.

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Bioaccessibility of arsenic from contaminated soils and alteration of the gut microbiome in an in vitro gastrointestinal model

机译：Bioaccessibility of arsenic from contaminated soils and alteration of the gut microbiome in an in vitro gastrointestinal model

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? 2022 Elsevier LtdArsenic exposure has been reported to alter the gut microbiome in mice. Activity of the gut microbiome derived from fecal microbiota has been found to affect arsenic bioaccessibility in an in vitro gastrointestinal (GI) model. Only a few studies have explored the relation between arsenic exposure and changes in the composition of the gut microbiome and in arsenic bioaccessibility. Here, we used simulated GI model system (GIMS) containing a stomach, small intestine, colon phases and microorganisms obtained from mouse feces (GIMS-F) and cecal contents (GIMS-C) to assess whether exposure to arsenic-contaminated soils affect the gut microbiome and whether composition of the gut microbiome affects arsenic bioaccessibility. Soils contaminated with arsenic did not alter gut microbiome composition in GIMS-F colon phase. In contrast, arsenic exposure resulted in the decline of bacteria in GIMS-C, including members of Clostridiaceae, Rikenellaceae, and Parabacteroides due to greater diversity and variability in microbial sensitivity to arsenic exposure. Arsenic bioaccessibility was greatest in the acidic stomach phase of GIMS (pH 1.5–1.7); except for GIMS-C colon phase exposed to mining-impacted soil in which greater levels of arsenic solubilized likely due to microbiome effects. Physicochemical properties of different test soils likely influenced variability in arsenic bioaccessibility (GIMS-F bioaccessibility range: 8–37%, GIMS-C bioaccessibility range: 2–18%) observed in this study.

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《Environmental Pollution》 |2022年第9期|1-9|共9页
作者
Griggs J.L.; Chi L.; Lu K.Fry R.C.Hanley N.M.Kohan M.Herbin-Davis K.Thomas D.J.Bradham K.D.;
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Department of Environmental Sciences and Engineering Gillings School of Global Public Health University of North Carolina at Chapel Hill;

Chemical Characterization and Exposure Division Center for Computational Toxicology & Exposure Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park;

Watershed and Ecosystem Characterization Division Center for Environmental Measurement and Modelling Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);美国《化学文摘》(CA);
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Bioaccessibility of arsenic from contaminated soils and alteration of the gut microbiome in an in vitro gastrointestinal model

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