EWALD: A macromolecular diffractometer for the second target station

Borgstahl Gloria E. O.; ODell William B.; Egli MartinKern Jan F.Kovalevsky AndreyLin Jiao Y. Y.Myles DeanWilson Mark A.Zhang WenZwart PetrusCoates Leighton

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EWALD: A macromolecular diffractometer for the second target station

机译：EWALD: A macromolecular diffractometer for the second target station

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Revealing the positions of all the atoms in large macromolecules is powerful but only possible with neutron macromolecular crystallography (NMC). Neutrons provide a sensitive and gentle probe for the direct detection of protonation states at near-physiological temperatures and clean of artifacts caused by x rays or electrons. Currently, NMC use is restricted by the requirement for large crystal volumes even at state-of-the-art instruments such as the macromolecular neutron diffractometer at the Spallation Neutron Source. EWALD's design will break the crystal volume barrier and, thus, open the door for new types of experiments, the study of grand challenge systems, and the more routine use of NMC in biology. EWALD is a single crystal diffractometer capable of collecting data from macromolecular crystals on orders of magnitude smaller than what is currently feasible. The construction of EWALD at the Second Target Station will cause a revolution in NMC by enabling key discoveries in the biological, biomedical, and bioenergy sciences. (C) 2022 Author(s).

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来源
《Review of Scientific Instruments》 |2022年第6期|064103-1-064103-9|共9页
作者
Borgstahl Gloria E. O.; ODell William B.; Egli MartinKern Jan F.Kovalevsky AndreyLin Jiao Y. Y.Myles DeanWilson Mark A.Zhang WenZwart PetrusCoates Leighton;
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作者单位

Neutron Scattering Div;

Oak Ridge Natl Lab;

Univ Nebraska LincolnIndiana Univ Sch MedLawrence Berkeley Natl LabEppley Inst Canc & Allied DisNatl Inst Stand & TechnolVanderbilt Univ;

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原文格式 PDF
正文语种英语
中图分类仪器、仪表;
关键词
MANGANESE SUPEROXIDE-DISMUTASE; PHOTOSYSTEM-II; LAUE DIFFRACTION; NEUTRON; CRYSTALLOGRAPHY; WATER; CRYSTALS; BINDING; SITE;

EWALD: A macromolecular diffractometer for the second target station

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